Clin Nucl Med 2000 Jul;25(7):532-5
Dichotomy between Tc-99m MDP bone scan and fluorine-18 fluorodeoxyglucose
coincidence detection positron emission tomography in patients with
non-Hodgkin's lymphoma.
Lee J, Park CH, Kim HC, Kim HS.
The authors report two cases of non-Hodgkin's lymphoma that were evaluated not
only by conventional staging work-up but also additional Tc-99m MDP bone scans
and fluorine-18 fluorodeoxyglucose (F-18 FDG) coincidence detection (CoDe)
positron emission tomographic (PET) imaging. There were discordant results
between the Tc-99m MDP bone scans and F-18 FDG CoDe PET. In the first case, the
bone marrow biopsy was positive, and F-18 FDG CoDe PET was consistent with a
malignancy, but the findings of the Tc-99m MDP bone scintiscan were negative. In
the second case, the bone marrow biopsy was negative, but F-18 FDG CoDe PET
revealed focal skeletal involvement, which improved markedly on the follow-up
study after chemotherapy. If skeletal involvement has a focal distribution and
is confined to the marrow cavity, both bone marrow biopsy and bone scintigraphy
can be falsely negative. In this situation, F-18 FDG PET is useful and
revealing.
