Clinical News

MRI-based biomarker tool can predict progression to dementia

By Amerigo Allegretto

The tool measures gray matter shrinkage in the brain, predicting when mild cognitive impairment progresses to dementia.

August 28, 2026

Is nitroglycerin necessary prior to photon-counting CT?

Sublingual nitroglycerin is routinely administered before CCTA to induce coronary vasodilation.

August 27, 2026

Representative case from the non-nitroglycerin cohort. A 92-year-old man who did not receive sublingual nitroglycerin because of severe aortic stenosis. The Agatston coronary artery calcium score was 5438. (A) Curved multiplanar reformatted CCTA image reconstructed at 0.4-mm slice thickness using a Bv60 kernel and QIR strength 3 demonstrates diffuse multifocal mild luminal stenoses related to extensive calcified atherosclerotic plaque. (B) Invasive coronary angiography confirmed multifocal mild stenoses without evidence of obstructive coronary artery disease.

PET outperforms CT in ovarian cancer

Peritoneal carcinomatosis in ovarian cancer is cancer that has spread from the ovaries to the peritoneum.

August 28, 2026

Comparison of contrast-enhanced CT (ceCT) and FAPI-PET in detecting peritoneal carcinomatosis in patient with advanced ovarian carcinoma. (A) ceCT shows subtle peritoneal thickening that is difficult to delineate. (B) Maximum-intensity-projection image demonstrating diffuse intense FAPI uptake corresponding to extensive peritoneal carcinomatosis. (C) FAPI-PET shows intense uptake corresponding with peritoneal carcinomatosis, with improved lesion conspicuity over ceCT.

Advanced ultrasound techniques improve soft tissue tumor evaluation

By Amerigo Allegretto

Both SWE and SMI can help distinguish benign from malignant soft tissue tumors.

August 26, 2026

Examples of ultrasound findings and techniques. (A) Images in a 39-year-old male patient with a mass in the left thigh. The mass is heterogeneous on the B-mode US image (compared with the patient in D) and showed increased microvascularity (superb microvascular imaging [SMI]) and shear-wave elastography (SWE) values. Undifferentiated pleomorphic sarcoma was diagnosed at biopsy (with pleomorphic rhabdomyosarcoma in surgical specimen). (B) Images in an 18-year-old male patient with a mass in the left leg. The mass is hypoechoic on the B-mode image, with no other findings suggestive of malignancy. The lesion is in contact with the cortex of the tibia, which is slightly irregular. CT revealed a doubtful anteromedial tibial erosion. The microvascular study demonstrated high vascularization, suggestive of malignancy. Periosteal Ewing sarcoma was diagnosed with both histologic and immunohistochemical confirmation. (C) Images in a 69-year-old female patient with a lump growing on the outside of the left leg. Multiple SWE examinations were performed (please note the high values obtained in the measurements, whereas the color map highlights the stiffness relative to adjacent tissues). SMI showed areas of increased vascularization to target for sampling. Undifferentiated spindle cell sarcoma was diagnosed at biopsy, with residual leiomyosarcoma in the surgical specimen after neoadjuvant therapy. (D) Images in a 56-year-old female patient with a mass in the right thigh. The mass is heterogeneous at both B-mode ultrasound (similar to patient A) and MRI (coronal T2-weighted spectral attenuated inversion recovery [SPAIR]; T1-weighted pre-contrast and postcontrast imaging), which even shows uptake after the administration of paramagnetic contrast material, which is traditionally suggestive of malignancy. Low values at SMI and elastography are suggestive of benignity. Spindle cell lipoma was diagnosed at biopsy, with atypical spindle cell lipomatous tumor in the surgical specimen.

Women's Imaging MinnieCast, Episode 16: Breast AI expectations versus performance

By Amerigo Allegretto

Azadeh Elmi, MD, shares results showing how breast imaging AI tools have modest clinical benefit in practice over expectations.

August 28, 2026

Minnie Cast Thumbnail (21)

CT reveals progressive growth pattern in incidental lung nodules

This pattern is most associated with a family history of lung cancer.

August 25, 2026

Serial axial chest CT scans demonstrating the longitudinal evolution of small pure ground-glass nodules (pGGNs) incidentally detected during a routine wellness assessment. (A) Images in a 37-year-old woman with a family history of lung cancer show a nodule with the progressive growth pattern (box). The baseline CT scan, obtained in October 2017, demonstrates a pure ground-glass nodules in the right lower lobe. Consecutive CT scans obtained from 2017 to 2022 show the continuous enlargement of the nodule during active surveillance. The maximum diameter of the nodule increased from 5.6 mm in 2017 to 10.2 mm in 2022. (B) Images in a 45-year-old man show a nodule with the indolent growth pattern (box). The baseline CT scan, obtained in April 2018, demonstrates a pure ground-glass nodules in the left lower lobe. Consecutive CT scans obtained from 2019 to 2023 show that the nodule remained radiographically stable during CT surveillance. The maximum diameter of the nodule was 5.4 mm in 2018 and 6.1 mm at the final surveillance scan in 2023.

Thymic health should be considered for radiotherapy planning

By Amerigo Allegretto

New evidence shows that unintended radiation exposure to the thymus during lung cancer treatment may lead to worse outcomes.

August 26, 2026

Radiation Treatment Cancer 400 (2)

Podcast: Where do MRI accident reports go?

MRI insiders quickly learned about the 2023 MRI accident in which a nurse was pinned to an MRI scanner by an ICU bed.

August 25, 2026

The Invisible Force Podcast Album Cover Auntminnie Jan 2026 Thumbnails

MRI detects ARIA in 21% of real-world donanemab patients

Of the 48 patients who underwent at least one surveillance MRI, 10 (21%) had an ARIA detected.

August 24, 2026

What independent clinics need to know before buying a CT scanner

By Joe Mason, Brandon Bush

In a new column, Brandon Bush and Joe Mason of Arineta offer CT purchasing advice for independent practices.

August 24, 2026

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Radiotherapy access could address gynecological cancer disparities

By Amerigo Allegretto

Inadequate radiotherapy infrastructure is one of several drivers of gynecological cancer disparities in LMICs.

August 24, 2026

Radiotherapy 400

Food insecurity linked to higher risk of death in breast cancer

Food-insecure regions are where people lack consistent access to enough affordable, nutritious food.

August 21, 2026

Food Insecurity

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