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(A) Averaged parametric images of F-18 SynVesT-1 BPND values and (B) F-18 FDG SUVR (60–90 minutes) values overlaid on anatomical (T1) images in MNI space show group differences between behavioral variant frontotemporal dementia (top) and healthy controls (middle). The color scale represents (A) BPND and (B) SUVR values. On the bottom, average z-score maps were generated to visualize regional reductions in F-18 SynVesT-1 BPND and F-18 FDG SUVR in bvFTD relative to healthy controls. For each voxel, z-scores were calculated as z = (bvFTD−meanHC )/SDHC. Negative z-scores indicate lower synaptic density or glucose metabolism in the bvFTD compared with controls in the regions. BPND, non-displaceable binding potential; bvFTD, behavioral variant frontotemporal dementia; F-18 FDG, F-18 fluorodeoxyglucose; MNI, Montreal Neurological Institute; SUVR, standardized uptake value ratio.
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(A) Averaged parametric images of F-18 SynVesT-1 BPND values and (B) F-18 FDG SUVR (60–90 minutes) values overlaid on anatomical (T1) images in MNI space show group differences between behavioral variant frontotemporal dementia (top) and healthy controls (middle). The color scale represents (A) BPND and (B) SUVR values. On the bottom, average z-score maps were generated to visualize regional reductions in F-18 SynVesT-1 BPND and F-18 FDG SUVR in bvFTD relative to healthy controls. For each voxel, z-scores were calculated as z = (bvFTD−meanHC )/SDHC. Negative z-scores indicate lower synaptic density or glucose metabolism in the bvFTD compared with controls in the regions. BPND, non-displaceable binding potential; bvFTD, behavioral variant frontotemporal dementia; F-18 FDG, F-18 fluorodeoxyglucose; MNI, Montreal Neurological Institute; SUVR, standardized uptake value ratio.
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