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Will Morton

[email protected]
Molecular Imaging
SPECT/CT viable over PET/CT for high-risk prostate cancer staging
Considering its broader accessibility, Tc-99m MIP-1404 CZT SPECT/CT may represent a practical alternative for primary staging.
July 24, 2026
Maximum intensity projection of Ga-68 PSMA-11 PET/CE-CT (A), Tc-99m MIP-1404 CZT SPECT/CT (B) and Tc-99m HDP CZT SPECT/CT (C) imaging. Ga-68 PSMA-11 PET/CE-CT and Tc-99m MIP-1404 CZT SPECT/CT showing tracer uptake in lymph nodes below the iliac bifurcation and above, paraaortic and left supraclavicular, bone uptake in the right proximal femur and right scapula (arrows). Tc-99m HDP CZT SPECT/CT did not show any uptake suspicious for metastatic disease. No sclerotic lesions suspicious of metastases were detected by the CT component in any of the studies. Fusion axial imaging of Ga-68 PSMA-11 PET/CE-CT (D) and Tc-99m MIP-1404 CZT SPECT/CT (E) showing uptake in lymph nodes in the left pelvic area below the iliac bifurcation (arrows). Fusion axial imaging of Ga-68 PSMA-11 PET/CE-CT (F) and Tc-99m MIP-1404 CZT SPECT/CT (G) showing uptake in the right proximal femur, not detected by Tc-99m HDP CZT SPECT/CT (H), (arrows).
Editor's Note
AuntMinnie.com Molecular Imaging Insider
In this edition of the Molecular Imaging Insider, we’ve highlighted a study showing that Lutetium-177 PSMA-617 spots early signs of benefit in men with metastatic hormone-sensitive prostate cancer.
July 21, 2026
Nuclear Medicine
Lutetium-177 PSMA-617 shows promise in earlier-stage prostate cancer
Across 14 studies, PSA50 response rates (the number of patients with at least a 50% drop in PSA) ranged from 44% to 100%.
July 21, 2026
Prostate Imaging
CT
LDCT screening criteria miss majority of Korean lung cancer patients
Just 35.4% of patients diagnosed with lung cancer met the 2023 American Cancer Society (ACS) screening criteria.
July 21, 2026
Lung Cancer
CT
CT reveals severe craniofacial, ocular trauma from pager blasts
Head injuries were nearly universal, affecting 93.2% of patients.
July 20, 2026
Adobe Stock 517622853
Molecular Imaging
Brain PET scans reveal neuron loss in long COVID
The findings suggest that treatments aimed at boosting dopamine release could be repurposed to treat long COVID.
July 14, 2026
Representative participant from each group shown. C-11 DTBZ non-displaceable binding potential (BPND) in voxels quantitated with simplified reference tissue model 2. Color scale indicates C-11 DTBZ BPND from 0 (black) to 3.5 (red), with reduced C-11 DTBZ BPND observed in the long COVID case compared to both healthy controls.
Digital X-Ray
First human x-rays in space deemed diagnostic
Crew surveys identified alignment and positioning, including of the subject, x-ray source, and detector, as the primary operational challenges.
July 14, 2026
Representative preflight, in-flight, and postflight chest radiographs. Radiographs of the chest were acquired (A) preflight by a crewmember, (B, C) in-flight on day 3 after launch (L+3) by a crewmember, and (D) postflight by a non-crew operator using the same imaging protocol.
Clinical News
New criteria evaluates treatment response in bone metastases
RECIBM-defined response classifications showed high agreement with established criteria and reclassified 19% of patients.
July 7, 2026
Response Evaluation Criteria in Bone Metastases (RECIBM) and metabolic criteria were used to detect a complete response missed at anatomic assessment. A 76-year-old male patient presented with 1 month of hemoptysis and was diagnosed with small cell lung cancer and bone metastases. Baseline (July 2022) F-18 FDG-PET/CT images (A, maximum intensity projection image; B–E, axial images) demonstrate FDG-avid lesions in the left lamina of the first lumbar vertebra (L1) (straight yellow arrows; maximum standardized uptake value, 2.74; peak standardized uptake value normalized to lean body mass, 1.59) and left ilium (curved yellow arrows; maximum standardized uptake value, 3.68; peak standardized uptake value normalized to lean body mass, 2.28). After seven chemotherapy cycles (December 2022), follow-up PET/CT images (F, maximum intensity projection image; G–J, axial images) show complete metabolic resolution of bony lesions (L1: maximum standardized uptake value, 1.32, and peak standardized uptake value normalized to lean body mass, 0.85; left ilium: maximum standardized uptake value, 1.48, and peak standardized uptake value normalized to lean body mass, 0.82), without apparent osteolytic or osteoblastic changes at CT. Assessment was stable disease (SD) according to the University of Texas MD Anderson Cancer Center (MDA) criteria but complete response (CR) or complete metabolic response (CMR) according to RECIBM, PET Response Criteria in Solid Tumors (PERCIST), and European Organization for Research and Treatment of Cancer (EORTC) criteria. The patient was alive as of September 30, 2025.
Economics
ACR/ASNC highlight changes in proposed 2027 HOPPS rule
Released by the Centers for Medicare and Medicaid Services (CMS) on July 2, the proposed rule has a 60-day comment period.
July 6, 2026
Acr Logo 2023 400
Molecular Imaging
PET/MRI can reduce the need for biopsies in prostate cancer
Prostate biopsies are associated with considerable morbidity, including pain, rectal bleeding, prostatitis, and urinary tract infections.
July 2, 2026
A visual abstract of the study.
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(A) Ga-68 NK224 PET/CT maximum intensity projection image (left), axial PET/CT images (center), and axial CT images (right) in a 43-year-old female participant with lung adenocarcinoma show lesions in the right cerebellum (blue arrow), right frontal lobe (red arrow), and sternum (green arrow) with low, intermediate, and high tracer uptake, respectively. Photomicrographs (scale bar, 100 μm) with hematoxylin-eosin (H&E) staining (center bottom) and programmed death ligand 1 (PD-L1) immunohistochemical (IHC) staining (right bottom) show high PD-L1 expression in the sternal lesion (tumor proportion score ≥ 50%).
Molecular Imaging
New immuno-PET tracer shows promise in lung cancer
Molecular imaging can provide whole-body visualization and quantitative assessment of PD-L1 expression.
Artificial intelligence (AI) assistance facilitates correct fracture identification in cases initially missed by human readers. A representative case is shown using anteroposterior radiographs in a 29-year-old male patient with wrist trauma (suspected nondisplaced transverse scaphoid fracture). The reader’s initial unaided assessment (top) resulted in a missed fracture, whereas with AI assistance (bottom), the fracture was correctly identified. The green box represents the fracture location as predicted by the AI tool, the blue box represents the reference standard annotation, and the red dots represent individual reader annotations.
Digital X-Ray
AI fracture detection device validated across three European hospitals
Artificial Intelligence Ai Medical Healthcare Tools 400
AI
Radiology Partners unit Mosaic petitions FDA on imaging AI regulation
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AI
FDA issues discussion paper on GenAI medical devices
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FAPI-PET/CT shows promise in hepatopancreatobiliary cancers
By Will Morton
FAPI-PET/CT could potentially improve noninvasive cancer staging, and, ultimately, clinical decision making.
August 13, 2026
Shown is a 69-year-old man with a cholangiocarcinoma in the distal common bile duct. F-18 FDG-PET/CT was negative where Ga-68 FAPI-46 PET/CT showed high focal FAPI uptake in the liver hilum and surrounding lymph nodes. a-d: F-18 FDG-PET/CT, e-h: Ga-68 FAPI-46 PET/CT. a, b, e, f: Maximum intensity projections, c, g: axial fusion images, d, h: non-contrast enhanced CT.
Longitudinal DBT could help improve long-term cancer risk prediction
By Amerigo Allegretto
A longitudinal DBT model outperformed other models based on mammography and clinical factors in predicting five-year cancer risk.
August 13, 2026
Breast Dbt 400
SBRT for prostate cancer cuts side effects, falls short on disease control
By Will Morton
A multinational team evaluated SBRT against moderately hypofractionated intensity-modulated radiation therapy in a phase III trial.
August 13, 2026
Prostate Imaging
DEXA reveals tea consumption supports bone health
By Will Morton
Moderate-frequency tea consumption was associated with better bone mineral status and more favorable longitudinal changes.
August 12, 2026
Adobe Stock 285124452
AI tools may not meet breast radiologists' expectations in practice
By Amerigo Allegretto
AI tools in breast imaging may have more modest clinical impact on recall and biopsy rates.
August 12, 2026
Breast Mammo Computer 400 (3)
Stepped reminders boost CT lung cancer screening
By Will Morton
Trial findings directly address the current lack of effective lung cancer screening interventions.
August 11, 2026
Lung Cancer
Model confidence, reader expertise affect reader-LLM collaboration
By Amerigo Allegretto
Successful human-LLM collaboration is associated with model confidence and reader expertise in chest imaging.
August 11, 2026
Example cases illustrate the double-edged role of large language model (LLM) rationale quality. (A) A 50-year-old female patient with a palpable anterior chest wall mass (correct diagnosis: solitary fibrous tumor of the pleura). The LLM incorrectly suggested synovial sarcoma but provided a persuasive rationale (quality score: 4 of 5), describing a well-defined nodule at axial contrast-enhanced CT spanning the pleura and intercostal space with heterogeneous strong enhancement. Four of five readers (80%) accepted the incorrect suggestion. FDG = fluorodeoxyglucose. (B) A 61-year-old male patient with diabetes presented with cough, sputum, and dyspnea (correct diagnosis: mucormycosis). The LLM correctly suggested mucormycosis with an excellent rationale (quality score: 5 of 5), integrating the reverse halo sign on serial axial CT images and rapidly progressive cavitary lesions. Three of five readers initially selected incorrect diagnoses; after LLM output, all five selected the correct diagnosis (100% acceptance). Blue and orange reader icons denote high- and low-expertise readers, respectively.
PET/CT predicts response to neoadjuvant therapy in breast cancer
By Will Morton
Monitoring neoadjuvant therapy response in HER2-positive breast cancer is challenging with existing tools.
August 11, 2026
Ga-68 HER2-PET/CT images before neoadjuvant therapy, at end of second cycle, and before surgery. (A) Baseline scan demonstrated soft-tissue lesion measuring approximately 2.3 × 2.2 cm in upper outer quadrant of left breast, with marked radiotracer uptake and SUVmax of 10.1. (B) At end of second cycle, imaging revealed residual lesion of approximately 2.2 × 1.0 cm in same region, without abnormal radiotracer accumulation. (C) Preoperative imaging demonstrated further reduction in lesion size to approximately 2.0 × 0.6 cm, with no abnormal tracer uptake detected.
5 factors that led to California workplace MRI accident
By Liz Carey
What happened at a Redwood City hospital in California in 2023.
August 11, 2026
The Invisible Force Podcast Album Cover Auntminnie Jan 2026 Thumbnails
NME breast lesions have high malignancy rate on MRI-guided biopsy
By Amerigo Allegretto
Biopsies from women with a known ipsilateral malignancy have a higher frequency of breast cancer.
August 10, 2026
Mri Breast 400
Many women interested in AI-based risk assessment for breast cancer
By Amerigo Allegretto
Survey findings also show that most women at higher risk are interested in additional screening tests.
August 10, 2026
Breast Cancer 400
CT 5-star quality rating system supports optimization
By Will Morton
The rating framework demonstrated robust reproducibility, with three-reader concordance reaching up to 93% in highly standardized centers.
August 7, 2026
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