Will Morton

[email protected]

Molecular Imaging

Bayer's PET agent meets endpoints in phase III cardiac amyloidosis study

Overall sensitivity was 94% (95% CI, 85% to 98%) and specificity was 86% (95% CI, 77% to 92%).

August 31, 2026

This figure shows fused I-124 evuzamitide positron emission tomography (PET)/computed tomography (CT) images from patients without amyloidosis and from patients with ATTR cardiac amyloidosis, early ATTR cardiac amyloidosis, light chain cardiac amyloidosis, gelsolin-mediated amyloidosis, and systemic organ amyloid. The columns represent radiological transaxial, sagittal, and coronal views except for the last row middle and far right columns, which are coronal projections. The blue asterisks represent physiological activity (tracer activity in the stomach and esophagus). The arrowheads represent pathological uptake. Note the small amount of cardiac uptake in the basal septum and the basal lateral walls (likely early ATTR cardiac amyloidosis), splenic uptake and pleural uptake in light chain amyloidosis, and cardiac and kidney uptake in gelsolin-mediated amyloidosis. The bright yellow color represents more tracer uptake.

Week in Review: IR tops specialties in compensation growth | Clinical imaging faculty stress and satisfaction | Former Philips engineer found guilty

IR's compensation growth, a survey measuring imaging staff's stress and satisfaction, and more made our top 10 list this week.

August 28, 2026

Is nitroglycerin necessary prior to photon-counting CT?

Sublingual nitroglycerin is routinely administered before CCTA to induce coronary vasodilation.

August 27, 2026

Representative case from the non-nitroglycerin cohort. A 92-year-old man who did not receive sublingual nitroglycerin because of severe aortic stenosis. The Agatston coronary artery calcium score was 5438. (A) Curved multiplanar reformatted CCTA image reconstructed at 0.4-mm slice thickness using a Bv60 kernel and QIR strength 3 demonstrates diffuse multifocal mild luminal stenoses related to extensive calcified atherosclerotic plaque. (B) Invasive coronary angiography confirmed multifocal mild stenoses without evidence of obstructive coronary artery disease.

Practice Management

Radiology faculty most stressed, least satisfied

Across faculty, technologists, and nurses, the most common stressors were generally system-level issues.

August 27, 2026

Shutterstock 1865403334

Malpractice suits tied to diagnostic errors, rising costs

Radiology malpractice claims were more likely than those in other specialties to involve diagnostic errors (71.3% versus 27.6%).

August 26, 2026

MRI detects ARIA in 21% of real-world donanemab patients

Of the 48 patients who underwent at least one surveillance MRI, 10 (21%) had an ARIA detected.

August 24, 2026

Molecular Imaging

PET/CT outperforms MRI after focal therapy for prostate cancer

No accurate noninvasive method has been validated to evaluate treatment response after focal therapy.

August 20, 2026

True-positive PSMA-PET with positive MRI in 74-year-old male with prostate cancer (Gleason score of 4 + 5; left anterior and posterior apex positive cores). (A) Left posterior peripheral apical to midprostate hyposignal visible on transaxial MRI. (B) No definite CT correlate evident (white arrow). (C) Focal high PSMA expression detectable in left posterior mid to base with SUVmax of 12.4 on transaxial fused delayed pelvic PET/CT (yellow arrow). (D) Focal high PSMA expression found in left midgland to base of prostate on maximum-intensity-projection image (yellow arrow).

Thermal ablation achieves long-term survival in kidney cancer

The 10-year overall survival (OS) and cancer-specific survival (CSS) rates were 68.5% and 75.5%.

August 20, 2026

Molecular Imaging

New immuno-PET tracer shows promise in lung cancer

Molecular imaging can provide whole-body visualization and quantitative assessment of PD-L1 expression.

August 18, 2026

(A) Ga-68 NK224 PET/CT maximum intensity projection image (left), axial PET/CT images (center), and axial CT images (right) in a 43-year-old female participant with lung adenocarcinoma show lesions in the right cerebellum (blue arrow), right frontal lobe (red arrow), and sternum (green arrow) with low, intermediate, and high tracer uptake, respectively. Photomicrographs (scale bar, 100 μm) with hematoxylin-eosin (H&E) staining (center bottom) and programmed death ligand 1 (PD-L1) immunohistochemical (IHC) staining (right bottom) show high PD-L1 expression in the sternal lesion (tumor proportion score ≥ 50%).

AI fracture detection device validated across three European hospitals

No differences in AI performance were observed across centers, and AI assistance was associated with higher reader sensitivity.

August 18, 2026

Artificial intelligence (AI) assistance facilitates correct fracture identification in cases initially missed by human readers. A representative case is shown using anteroposterior radiographs in a 29-year-old male patient with wrist trauma (suspected nondisplaced transverse scaphoid fracture). The reader’s initial unaided assessment (top) resulted in a missed fracture, whereas with AI assistance (bottom), the fracture was correctly identified. The green box represents the fracture location as predicted by the AI tool, the blue box represents the reference standard annotation, and the red dots represent individual reader annotations.

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Representative longitudinal chest CT images and five-year parametric response mapping (PRM), pulmonary vascular CT reconstructions, and hyperpolarized xenon-129 (Xe-129) ventilation MRI scans from survivors of nonsevere and severe COVID-19 pneumonia. (A–F) Images in a 68-year-old male survivor of nonsevere COVID-19 pneumonia, (G–L) 62-year-old male survivor of severe COVID-19 pneumonia, and (M–R) 55-year-old male survivor of severe COVID-19 pneumonia. For each participant, the first three columns show coronal chest CT images from the acute phase (A, G, M), two-year follow-up (B, H, N), and five-year follow-up (C, I, O) (left to right). The fourth column (D, J, P) shows a coronal PRM image for each participant at five-year follow-up derived from paired inspiratory and expiratory CT scans, showing the spatial distribution of lung functional categories. Green indicates normal lung tissue, yellow indicates functional small airway disease, and red indicates emphysema. The second-to-last column shows volume-rendered small pulmonary vessel visualization (red) at five-year follow-up per participant (E, K, Q). The column on the far right (F, L, R) shows a hyperpolarized Xe-129 MRI ventilation defect percentage (VDP) map at five-year follow-up per participant. Dark blue represents high Xe-129 signal intensity, corresponding to well-ventilated lung regions, whereas red represents no Xe-129 signal intensity, corresponding to ventilation defects. At five-year follow-up, the 68-year-old survivor of nonsevere COVID-19 pneumonia (top row) showed near-complete radiologic resolution, no respiratory symptoms, and preserved pulmonary function. In contrast, the 62-year-old survivor of severe COVID-19 pneumonia (middle row) showed persistent fibrotic linear opacities without respiratory symptoms and mildly reduced pulmonary function. The 55-year-old survivor of severe COVID-19 pneumonia (bottom row) showed persistent scattered fibrotic linear opacities and focal emphysematous changes in both lungs, with dyspnea and impaired gas exchange function. The VDP values obtained from F, L, and R were 7.7%, 7.1%, and 6.3%, respectively.

What are the effects of COVID-19 pneumonia after 5 years?

After five years, residual lesions persisted in 35.6% of survivors (37 of 104).

Nuclear Medicine

USC researchers develop “plug-and-play" platform for PET tracers

Representative MRI scans for which the independently assigned imaging-derived extranodal extension (iENE) grades differed among the readers. (A) Axial and sagittal images in a 56-year-old male patient with nasopharyngeal carcinoma and cervical nodal metastases. Readers 1 and 3 interpreted the finding as a metastatic lymph node invading the left sternocleidomastoid muscle (arrow) and assessed an iENE grade of 3, whereas reader 2 assigned a grade of 2. After joint review, the radiologists reached a consensus on the absence of definite sternocleidomastoid muscle invasion, and the final iENE grade was 2. (B) Axial and sagittal images in a 52-year-old male patient with nasopharyngeal carcinoma and cervical nodal metastases. Reader 1 interpreted the findings as a single enlarged metastatic lymph node and assessed an iENE grade of 1, whereas readers 2 and 3 interpreted them as two coalescent metastatic lymph nodes (arrows) and assessed a grade of 2. After joint review, the radiologists reached a consensus on the coalescence of the two metastatic lymph nodes, and the final iENE grade was 2.

Image-based grading system estimates nasopharyngeal carcinoma severity

Astro

ASTRO 2026 to center on translating radiotherapy data into dialogue

Free webinar for radiology leaders

Free webinar for radiology leaders

Recalls stable for radiation oncology tools despite tech advancements

By Amerigo Allegretto

While radiation oncology devices using AI or machine learning are increasingly entering the market, recalls may be plateauing.

September 18, 2026

Ultrasound MinnieCast, Episode 17: Elastography holds promise toward expanded role

By Amerigo Allegretto

David Fetzer, MD, discusses current applications and issues in the world of elastography.

September 18, 2026

Minnie Cast Thumbnail (25)

Minibeam radiotherapy performs well in first clinical trial

The technique delivers very high doses of radiation through closely spaced, extremely narrow beams.

September 17, 2026

Radiation oncology medical physicist Michael Grams, MD, holds a device called a tungsten collimator that divides a conventional radiation beam into submillimeter-wide beamlets.

USPSTF names radiologist to task force; ACR responds

By Amerigo Allegretto

Dennis Wulfeck, MD, has 33 years of experience in diagnostic imaging, and his appointment to the task force has the support of the ACR.

September 17, 2026

Capitol Hill Government 400

Individual specialization may drive IR procedure complexity

By Amerigo Allegretto

Practice- and radiologist-level IR specializations showed associations with greater procedural complexity.

September 17, 2026

Interventional Radiology 400

AI boosts brain aneurysm detection on CT angiography

AI preferentially detected smaller aneurysms (< 3 mm), while radiologists more often identified larger aneurysms (3 to 5 mm and > 5 mm).

September 17, 2026

ASTRO issues first radiation therapy guideline for bladder cancer

By AuntMinnie.com staff writers

Bladder preservation should be presented as a curative treatment option alongside radical cystectomy.

September 16, 2026

LLM on par with head-and-neck subspecialists in analyzing MRI reports

By Amerigo Allegretto

GPT-5-Thinking yields similar diagnostic accuracy compared to subspecialists focusing on orbital and head-and-neck MRI.

September 16, 2026

Mri Brain Head 400

CCTA links neighborhood income to atherosclerosis

The relationship between socioeconomic disparities and imaging-defined coronary atherosclerosis on CCTA has not been fully understood.

September 15, 2026

Chest CT muscle attenuation predicts future bone density loss

Muscle and bone loss commonly coexist with aging, but potential links between paraspinal muscle and thoracic vertebral bone mineral density loss remain poorly understood

September 15, 2026

Study overview. (A) Volumetric segmentation of the paraspinal musculature was performed for 1,316 participants. (B) Manual segmentation was performed, the results were compared with the volumetric segmentation results, and the Dice score and the intersection over union were calculated. (C) The three-dimensional segmentations from T1 through T10 were individually extracted and combined into a single volume for analyses. (D) Muscle volume and median muscle attenuation were derived from the segmentation volumes. (E) Analyses were performed to assess the correlation of the paraspinal muscle attenuation and volume with the bone mineral density and the ability to predict vertebral fractures. NIFTI = Neuroimaging Informatics Technology Initiative, 3D = three-dimensional.

Curium gets FDA approval for Lu-177 injection for GEP-NETs

By AuntMinnie.com staff writers

The radioligand therapy delivers targeted radiation to GEP-NETs by binding to somatostatin receptors expressed on these tumors.

September 15, 2026

Approved Stamp 400

Brains age faster among residents in disadvantaged neighborhoods

By Amerigo Allegretto

MRI data show that living in disadvantaged neighborhoods is tied to adverse brain health.

September 15, 2026

National and state neighborhood-level disadvantage rankings of the study patients. (A) National disadvantage rankings are shown. Left: area deprivation scores mapped onto the state of Wisconsin, where the study sample resides, with national ranking deciles shown. Blue indicates less disadvantaged neighborhoods, whereas red indicates more disadvantaged neighborhoods. Right: histogram quantifying the number of patients in each Area Deprivation Index (ADI) decile. (B) Same as A, but state ranking deciles are shown. The distributions of both the national and state-level ADI rankings of the patients were skewed toward less disadvantaged neighborhoods. Maps were obtained from reference 36.

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