Will Morton

Molecular Imaging
PET/MRI detects arterial inflammation in prostate cancer patients
Androgen deprivation therapy (ADT) is widely used in advanced prostate cancer, yet is associated with increased cardiovascular events such as stroke and heart attacks.
July 31, 2026
Representative axial fused F-18 FDG-PET/MRI images and corresponding anatomic MRI images from a patient imaged at baseline and after initiation of androgen deprivation therapy are shown. Each row displays a distinct vascular territory. White arrows indicate focal areas of increased tracer uptake within the arterial wall, where spherical volumes of interest (VOIs) were placed for maximum standardized uptake value (SUVmax) measurement. Additional VOIs were placed in the superior vena cava and inferior vena cava for blood-pool activity sampling. SUVmax values from the arterial VOIs were extracted on the corresponding PET images and normalized to the blood-pool mean standardized uptake value to derive the maximum target-to-background ratio.
CT
Nongated CT scans can predict heart disease risk
Subjects with moderate and severe CAC scores on nongated CT had significantly higher risk of coronary heart disease risk.
July 30, 2026
Heart 1
CT
CT radiation doses have fallen sharply over past decade
The largest reductions appeared in chest examinations with contrast material, where diagnostic reference levels fell 31%.
July 28, 2026
Bar graphs show comparison of volume CT dose index (CTDIvol) (A) achievable doses (50th percentile) and (B) diagnostic reference levels (75th percentile) between 2014 (see reference 4 by Kanal et al) and 2025 (present study) for 10 common CT examination types performed without contrast (w/o) and with contrast (w/). Across all 10 adult CT examination categories, CTDIvol achievable doses and diagnostic reference levels generally decreased from 2014 to 2025, with the largest reductions for torso examinations (chest; abdomen-pelvis; and combined chest, abdomen, and pelvis), intermediate reductions for neck and cervical spine, and minimal change for head examinations.
Molecular Imaging
SPECT/CT viable over PET/CT for high-risk prostate cancer staging
Considering its broader accessibility, Tc-99m MIP-1404 CZT SPECT/CT may represent a practical alternative for primary staging.
July 24, 2026
Maximum intensity projection of Ga-68 PSMA-11 PET/CE-CT (A), Tc-99m MIP-1404 CZT SPECT/CT (B) and Tc-99m HDP CZT SPECT/CT (C) imaging. Ga-68 PSMA-11 PET/CE-CT and Tc-99m MIP-1404 CZT SPECT/CT showing tracer uptake in lymph nodes below the iliac bifurcation and above, paraaortic and left supraclavicular, bone uptake in the right proximal femur and right scapula (arrows). Tc-99m HDP CZT SPECT/CT did not show any uptake suspicious for metastatic disease. No sclerotic lesions suspicious of metastases were detected by the CT component in any of the studies. Fusion axial imaging of Ga-68 PSMA-11 PET/CE-CT (D) and Tc-99m MIP-1404 CZT SPECT/CT (E) showing uptake in lymph nodes in the left pelvic area below the iliac bifurcation (arrows). Fusion axial imaging of Ga-68 PSMA-11 PET/CE-CT (F) and Tc-99m MIP-1404 CZT SPECT/CT (G) showing uptake in the right proximal femur, not detected by Tc-99m HDP CZT SPECT/CT (H), (arrows).
Editor's Note
AuntMinnie.com Molecular Imaging Insider
In this edition of the Molecular Imaging Insider, we’ve highlighted a study showing that Lutetium-177 PSMA-617 spots early signs of benefit in men with metastatic hormone-sensitive prostate cancer.
July 21, 2026
Nuclear Medicine
Lutetium-177 PSMA-617 shows promise in earlier-stage prostate cancer
Across 14 studies, PSA50 response rates (the number of patients with at least a 50% drop in PSA) ranged from 44% to 100%.
July 21, 2026
Prostate Imaging
CT
LDCT screening criteria miss majority of Korean lung cancer patients
Just 35.4% of patients diagnosed with lung cancer met the 2023 American Cancer Society (ACS) screening criteria.
July 21, 2026
Lung Cancer
CT
CT reveals severe craniofacial, ocular trauma from pager blasts
Head injuries were nearly universal, affecting 93.2% of patients.
July 20, 2026
Adobe Stock 517622853
Molecular Imaging
Brain PET scans reveal neuron loss in long COVID
The findings suggest that treatments aimed at boosting dopamine release could be repurposed to treat long COVID.
July 14, 2026
Representative participant from each group shown. C-11 DTBZ non-displaceable binding potential (BPND) in voxels quantitated with simplified reference tissue model 2. Color scale indicates C-11 DTBZ BPND from 0 (black) to 3.5 (red), with reduced C-11 DTBZ BPND observed in the long COVID case compared to both healthy controls.
Digital X-Ray
First human x-rays in space deemed diagnostic
Crew surveys identified alignment and positioning, including of the subject, x-ray source, and detector, as the primary operational challenges.
July 14, 2026
Representative preflight, in-flight, and postflight chest radiographs. Radiographs of the chest were acquired (A) preflight by a crewmember, (B, C) in-flight on day 3 after launch (L+3) by a crewmember, and (D) postflight by a non-crew operator using the same imaging protocol.
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MRI
MRI detects ARIA in 21% of real-world donanemab patients
Of the 48 patients who underwent at least one surveillance MRI, 10 (21%) had an ARIA detected.
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CT
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Radiation Oncology/Therapy
Radiotherapy access could address gynecological cancer disparities
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More in Home
AI fracture detection device validated across three European hospitals
By Will Morton
No differences in AI performance were observed across centers, and AI assistance was associated with higher reader sensitivity.
August 18, 2026
Artificial intelligence (AI) assistance facilitates correct fracture identification in cases initially missed by human readers. A representative case is shown using anteroposterior radiographs in a 29-year-old male patient with wrist trauma (suspected nondisplaced transverse scaphoid fracture). The reader’s initial unaided assessment (top) resulted in a missed fracture, whereas with AI assistance (bottom), the fracture was correctly identified. The green box represents the fracture location as predicted by the AI tool, the blue box represents the reference standard annotation, and the red dots represent individual reader annotations.
Radiology Partners unit Mosaic petitions FDA on imaging AI regulation
By AuntMinnie.com staff writers
The petition seeks clarity on the regulation of AI vision language models used for diagnostic medical image analysis.
August 18, 2026
Artificial Intelligence Ai Medical Healthcare Tools 400
FDA issues discussion paper on GenAI medical devices
By AuntMinnie.com staff writers
The paper covers risk assessment, pre-market evaluation, and considerations around foundation models and agentic AI systems.
August 18, 2026
Fda Button 400
CT for breast radiotherapy detects ischemic heart disease risk
By Will Morton
As survival after early-stage breast cancer improves, cardiovascular disease has emerged as an increasingly prominent competing risk in older women.
August 17, 2026
Heart 1
MWA may have long-term benefits for renal cell cancer patients
By Amerigo Allegretto
MWA with CT or CEUS guidance leads to "excellent" 10-year survival rates and with minimal complications.
August 17, 2026
Kidneys 400
Radiation-related cancer mortality higher for U.S. flight crew
By Amerigo Allegretto
Results point to prolonged exposure to cosmic radiation at commercial flight attitudes.
August 17, 2026
Airplane Takeoff 400
AI system cuts DEXA turnaround time, improves reports
By Will Morton
Median report creation and turnaround times dropped to under one minute.
August 14, 2026
Dexa
PAE effective in men over 80 years old
By Will Morton
Findings support PAE as an important minimally invasive treatment option for elderly patients who are nonsurgical candidates.
August 14, 2026
Prostate Imaging2
Prone positioning may benefit women undergoing PBI
By Amerigo Allegretto
Prone positioning may lead to lower heart and lung doses and lower rates of acute dermatitis.
August 14, 2026
Radiation Therapy Suite 400
Lantheus wins FDA approval for tau PET imaging agent
By AuntMinnie.com staff writers
Tauklarify, previously known as MK-6240, has been approved for tau PET imaging in adults with cognitive impairment being evaluated for Alzheimer's disease.
August 14, 2026
Approved Stamp 400
Women's Imaging MinnieCast, Episode 15: BACs and heart disease risk
By Amerigo Allegretto
Laurie Margolies, MD, shares insights on how breast arterial calcifications (BACs) on mammograms should be managed.
August 14, 2026
Minnie Cast Thumbnail (19)
FAPI-PET/CT shows promise in hepatopancreatobiliary cancers
By Will Morton
FAPI-PET/CT could potentially improve noninvasive cancer staging, and, ultimately, clinical decision making.
August 13, 2026
Shown is a 69-year-old man with a cholangiocarcinoma in the distal common bile duct. F-18 FDG-PET/CT was negative where Ga-68 FAPI-46 PET/CT showed high focal FAPI uptake in the liver hilum and surrounding lymph nodes. a-d: F-18 FDG-PET/CT, e-h: Ga-68 FAPI-46 PET/CT. a, b, e, f: Maximum intensity projections, c, g: axial fusion images, d, h: non-contrast enhanced CT.
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