Circle Cardiovascular Imaging (Circle CVI) has received clearance from the U.S. Food and Drug Administration (FDA) for cvi42 | Plaque, AI software for plaque analysis on coronary CT angiography (CCTA).
cvi42 | Plaque integrates into existing CT workflows and is compatible with all major vendor systems. Ultimately, the software provides clinicians with greater control over their data, improved study processing times, and enhanced workflow efficiency, the company said.
Medicare currently covers AI-enabled coronary plaque analysis from CCTA with Category III CPT code 0625T, but effective January 2026, AI-enabled coronary plaque analysis will be covered by permanent Category I CPT code 75XX6, Circle CVI noted.
![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
