IMS begins Italian digital mammo trial

AuntMinnie.com staff writers

Nov 19, 2001

IMS (Internazionale Medico Scientifica) of Bologna, Italy said it has begun the first clinical trial of its new full-field digital mammography system, known as Giotto Image MD.

The 9-month trial will include at least 500 patients at the Ospedale Maggiore of Bologna, and will be led by breast specialist Dr. Gianni Saguatti, IMS said.

IMS marketing director Achille Albanese told AuntMinnie.com that the firm has been developing the scanner since 1996. Giotto Image MD relies on amorphous selenium-based digital detector technology developed by detector manufacturer and Analogic subsidiary Anrad (formerly Noranda) of St. Laurent, Canada.

IMS gained its first experience in digital mammography with the spot digital stereotactic Prone biopsy unit it developed together with Tucson, AZ-based Medoptics, Albanese said.

By AuntMinnie.com staff writers
November 20, 2001

Copyright © 2001 AuntMinnie.com

(A) Free-response receiver operating characteristic (FROC) curve for DBT-DINO and DINOv2 (Meta AI) on the detection task. DINOv2 achieved higher sensitivity than DBT-DINO across most false-positive thresholds. (B) Detection rates of DBT-DINO and DINOv2 for lesions that were ultimately found to be benign (n = 70) and lesions that were found to be cancerous (n = 66). Error bars represent 95% CIs estimated via patient-level bootstrapping with 1000 repetitions. Both models showed similar detection rates for cancerous lesions, whereas DINOv2 detected more benign lesions than DBT-DINO. (C) Example bounding box predictions for DBT-DINO and DINOv2 on the detection test set. Each image is a single two-dimensional section from a three-dimensional digital breast tomosynthesis volume; the first column shows a mediolateral oblique view, and the second and third columns show craniocaudal views. Both models struggled to detect very small lesions, such as the 3-mm-diameter lesion shown in the first column. FP = false positive.

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Images in a 70-year-old asymptomatic woman with a prior excisional biopsy in the left breast yielding lobular carcinoma in situ 3 years earlier. Screening contrast-enhanced mammography (CEM) was performed, which was considered a prevalence screen as the woman had no prior breast MRI in the past 3 years and no prior CEM. (A) Low-energy (26–30 kVp) mediolateral oblique (MLO) and (B) craniocaudal (CC) views show surgical clips but no abnormality. (C) Recombined MLO and (D) CC images show an enhancing mass in the medial left breast (arrows). Biopsy revealed invasive lobular carcinoma. Size was 0.2 cm; tumor grade II/III; negative lymph nodes; and estrogen receptor–positive, progesterone receptor–positive, and human epidermal growth factor receptor 2–negative.

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