Thursday, December 4 | 10:40 a.m.-10:50 a.m. | SSQ10-02 | Room E450B
MR-guided transurethral ultrasound ablation is a feasible, minimally invasive, and safe way to treat organ-confined prostate cancer, according to research to be presented on Thursday.Presenter Dr. Maya Mueller-Wolf, from the German Cancer Research Center in Heidelberg, and colleagues included 30 patients with biopsy-proven, low-risk prostate cancer in a phase I clinical study. Mueller-Wolf's group performed the technique using Profound Medical's PAD-105 prostate ablation device, in conjunction with a 3-tesla MR scanner from Siemens Healthcare.
The team confirmed that cancer cells were destroyed using contrast-enhanced MR immediately after the procedure and at the 12-month follow-up. Median treatment time and prostate volume were 36 minutes and 44 mL, respectively.
The procedure was well-tolerated by all patients, and there were no intraoperative complications, according to the researchers. They further confirmed that the treatment was successful with a median prostate-specific antigen (PSA) decrease from 5.8 ng/mL to 0.7 ng/mL at one month after the procedure in 24 patients.
Whole-gland ablation can be safely and accurately performed using the technology, the group concluded.
![Examples of ultrasound findings and techniques. (A) Images in a 39-year-old male patient with a mass in the left thigh. The mass is heterogeneous on the B-mode US image (compared with the patient in D) and showed increased microvascularity (superb microvascular imaging [SMI]) and shear-wave elastography (SWE) values. Undifferentiated pleomorphic sarcoma was diagnosed at biopsy (with pleomorphic rhabdomyosarcoma in surgical specimen). (B) Images in an 18-year-old male patient with a mass in the left leg. The mass is hypoechoic on the B-mode image, with no other findings suggestive of malignancy. The lesion is in contact with the cortex of the tibia, which is slightly irregular. CT revealed a doubtful anteromedial tibial erosion. The microvascular study demonstrated high vascularization, suggestive of malignancy. Periosteal Ewing sarcoma was diagnosed with both histologic and immunohistochemical confirmation. (C) Images in a 69-year-old female patient with a lump growing on the outside of the left leg. Multiple SWE examinations were performed (please note the high values obtained in the measurements, whereas the color map highlights the stiffness relative to adjacent tissues). SMI showed areas of increased vascularization to target for sampling. Undifferentiated spindle cell sarcoma was diagnosed at biopsy, with residual leiomyosarcoma in the surgical specimen after neoadjuvant therapy. (D) Images in a 56-year-old female patient with a mass in the right thigh. The mass is heterogeneous at both B-mode ultrasound (similar to patient A) and MRI (coronal T2-weighted spectral attenuated inversion recovery [SPAIR]; T1-weighted pre-contrast and postcontrast imaging), which even shows uptake after the administration of paramagnetic contrast material, which is traditionally suggestive of malignancy. Low values at SMI and elastography are suggestive of benignity. Spindle cell lipoma was diagnosed at biopsy, with atypical spindle cell lipomatous tumor in the surgical specimen.](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/08/images-radiol250278fig2.APCFLSvX6p.jpg?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
