ClariPi debuts new software at RSNA 2021

AuntMinnie.com staff writers

Nov 28, 2021

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Software developer ClariPi is showcasing new artificial intelligence (AI) products at the RSNA 2021 conference in Chicago.

ClariACE is a software-based iodine contrast boost solution that addresses the need to minimize contrast medium side effects in contrast-enhanced CT scans, the company said. ClariPi also introduced ClariPulmo, a fully automated AI-powered 3D reporting solution for COVID-19 pneumonia and emphysema.

Finally, the company is also touting ClariOsteo, an AI-based precision bone healthcare solution used with both low-dose and ultralow-dose CT images.

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Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).

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Air pollution tied to worse coronary disease on CT, especially in women

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The strongest effects of pollution exposure is seen in women, even at moderate levels typical of high-income countries.

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Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).

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The document was crafted by a team from King's College London in the U.K.

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Ct Scanner Patient Girl 400

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Exemplary cases from the ESCAPE-MeVO trial illustrating good, moderate, and poor collateral status at baseline multiphase CT angiography (CTA). (A) Sagittal image shows a left anterior middle cerebral artery medium-vessel occlusion (MeVO) with a calcified thrombus (arrow). (B–D) Axial images show the (B) arterial, (C) peak venous, and (D) delayed venous phases of the baseline multiphase CTA examination. The affected brain parenchyma is highlighted by the dashed outline. The collateral status is good, with early filling of more than 50% of the leptomeningeal collaterals compared with the contralateral side in the arterial phase (B), and there is no delayed washout in the peak venous (C) or delayed venous phase (D). (E) Sagittal image shows a left anterior middle cerebral artery MeVO (arrow). (F–H) Axial images show the (F) arterial, (G) peak venous, and (H) delayed venous phases of the baseline multiphase CTA examination. The affected brain parenchyma is highlighted by the dashed outline. The collateral status is moderate (more than 25% but less than 50% filling of the leptomeningeal collaterals in the affected territory compared with the contralateral side) on the arterial (F) and peak venous (G) phase, and there is delayed washout in the late venous phase (H). (I) Sagittal image shows a posterior dominant middle cerebral artery MeVO (arrow). (J–L) Axial images show the (J) arterial, (K) peak venous, and (L) delayed venous phases of the baseline multiphase CTA examination. The affected brain parenchyma is highlighted by the dashed outline. The collateral status is poor, with almost no collateral filling.

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Case example of a false-negative AI result. An 85-year-old female presented to the emergency department with dyspnea. Axial 0.625-mm from CT pulmonary angiography examination with contrast (CTPA) images demonstrate a thin, linear right-sided filling defect extending from the right interlobar pulmonary artery (A and B, red arrows) into the right middle lobar artery (B, yellow arrow), consistent with acute pulmonary embolism (PE). The finding was described in the radiology report; however, the AI result was negative for PE. Adjudication was consistent with acute PE.

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