November 7, 2019 --
FFR-CT is increasingly being integrated into the diagnostic workup for chronic stable chest pain, though its utility for acute chest pain is less understood, noted Dr. Richard Bayer and colleagues from the Medical University of South Carolina.
The researchers, thus, set out to determine the potential benefits of using FFR-CT in addition to CCTA to evaluate emergency chest pain. They used commercially available software for their FFR-CT analysis, which had a turnaround time of approximately three and a half hours.
In all, they examined 31 patients with acute chest pain; roughly half were positive for stenosis on CCTA and had an FFR-CT score of less than 0.8. Among those with a positive FFR-CT, 20% had a major adverse cardiac event within the first 30 days following initial examination. In contrast, only one patient with a negative FFR-CT (6%) had a major adverse event.
The findings of this preliminary study suggested that FFR-CT plus CCTA could help estimate the risk of major adverse events in emergency patients more effectively than other evaluation strategies, including CCTA alone. Ultimately, FFR-CT could help differentiate between patients who would benefit from further invasive testing and those who could safely be discharged, the researchers concluded.