Image visualization software firm Imago Systems has signed a multiyear agreement with the Mayo Clinic that includes financial and clinical trial support for the company's ICE Reveal software for breast imaging.
ICE Reveal features algorithms designed to transform grayscale images such as mammograms into more clearly defined, visually apparent, and qualitatively distinct patterns. The Mayo Clinic will spearhead Imago's pilot and pivotal studies to clinically validate the visual intelligence software as applied to screening mammograms, the company said.
The Mayo Clinic has a financial interest in the technology, and it will use revenue it receives from the platform to support patient care, education, and research, Imago noted.













![A normal mammogram confirmed by three-year radiologic follow-up illustrates reader-marked regions of interest (ROIs) during (A) unaided (round 1) and (B) artificial intelligence (AI)–assisted (round 2) reading. Each colored dot represents an ROI for recall by a human reader. Readers could mark more than one ROI per case, represented by multiple dots of the same color. During AI-assisted reading, the AI system displayed three visible prompts: two with suspicion of malignancy scores of 35% (left mediolateral oblique [L MLO] and craniocaudal [L CC]) and one with a suspicion of malignancy score of 10% (right craniocaudal [R CC]), shown as polygonal overlays. Without AI, six of 10 readers (60%) marked a false-positive ROI. With AI assistance, this fell to two of 10 (20%). R MLO = right mediolateral oblique.](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/07/2026-07-14-radiology-mammogram-ai-auto-bias.H0bYO8QlWs.jpg?auto=format%2Ccompress&fit=crop&h=112&q=70&w=112)





