Volumetric breast density techniques compare well with MRI results, according to a study of Matakina International's VolparaDensity software published in PLOS One (December 4, 2013) and presented at RSNA 2013 in Chicago.
Researchers at the University of California, San Francisco (UCSF) compared several automated methods of assessing volumetric breast density from digital screening mammograms and evaluated their agreement with a quantitative volumetric MRI-based technique. The results demonstrated that VolparaDensity had the highest correlation with MRI for fibroglandular volume, outperforming the other commercial methods.
VolparaDensity is used to assess density from both digital mammography and tomosynthesis images and help evaluate who might benefit from additional screening, Matakina said. Highly correlated to breast MR assessments, VolparaDensity automatically generates an objective measurement of volumetric breast density and a BI-RADS breast density category. To date, more than 2 million women have had their volumetric breast density analyzed using VolparaDensity, the company said.










![A normal mammogram confirmed by three-year radiologic follow-up illustrates reader-marked regions of interest (ROIs) during (A) unaided (round 1) and (B) artificial intelligence (AI)–assisted (round 2) reading. Each colored dot represents an ROI for recall by a human reader. Readers could mark more than one ROI per case, represented by multiple dots of the same color. During AI-assisted reading, the AI system displayed three visible prompts: two with suspicion of malignancy scores of 35% (left mediolateral oblique [L MLO] and craniocaudal [L CC]) and one with a suspicion of malignancy score of 10% (right craniocaudal [R CC]), shown as polygonal overlays. Without AI, six of 10 readers (60%) marked a false-positive ROI. With AI assistance, this fell to two of 10 (20%). R MLO = right mediolateral oblique.](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/07/2026-07-14-radiology-mammogram-ai-auto-bias.H0bYO8QlWs.jpg?auto=format%2Ccompress&fit=crop&h=112&q=70&w=112)






