Molecular Imaging: Page 4

PET reveals patterns underlying cognitive decline in patients with DLB
By Will Morton
F-18 FDG-PET imaging in patients with dementia with Lewy bodies (DLB) has shown that brain hypo- and hypermetabolism may have different affects on cognition.
January 5, 2024
DLB-hypo (hypometabolic changes in dementia with Lewy bodies) was characterized by relatively reduced bilateral metabolic activity (color-coded blue) in the bilateral parietal, temporal, and occipital cortices, while DLB-hyper (hypermetabolic changes in dementia with Lewy bodies) showed relatively increased metabolic activity (color-coded red) in the cerebellum, bilateral sensorimotor, orbitofrontal, insular, and parahippocampal cortices, bilateral putamen, globus pallidum, hippocampus, and amygdala. Image courtesy of npj Parkinson’s Disease.
FAPI-PET outperforms FDG-PET in diagnosing pancreatic cancer
By Will Morton
F-18 FAPI-PET/CT is superior to F-18 FDG-PET/CT for diagnosing and staging patients with pancreatic cancer.
January 5, 2024
Typical PET (top), PET/CT (middle), and CT and MR (bottom) images of primary tumor obtained using both radiotracers in representative patients (A and B). Tumor is marked by arrows. DWI = diffusion-weighted imaging. Image courtesy of the Journal of Nuclear Medicine.
PET/CT predicts brain tumors in melanoma patients
By Will Morton
PET/CT scans have the potential to predict brain metastasis in melanoma patients.
January 3, 2024
A 49-year-old patient with primary clinical stage III melanoma underwent F-18 FDG-PET. The primary tumor Breslow thickness was 6.5 mm. On initial F-18 FDG-PET images, this patient had a high SUVmax (52), resulting in limited survival with the occurrence of brain metastasis in the first year of follow-up (horizontal arrow). Notably, during the course of the treatment, the patient underwent surgical removal of the primary tumor as well as lymph node dissection, followed by neoadjuvant radiotherapy and immunotherapy. Image courtesy of Cancers.
PET/CT scans ‘crucial’ in patients with NK/T-cell lymphoma
By Will Morton
PET/CT has significant advantages over conventional methods for lesion detection and staging in patients with natural killer/T-cell lymphoma.
December 22, 2023
A 50-year-old man with recently diagnosed nasal-type NK/T-cell lymphoma underwent an F-18 FDG-PET/CT scan (A–D) for initial staging. Maximum-intensity-projection image (A) shows hypermetabolic lesions in both ethmoid sinus (thin arrow), both cervical lymphatic chains (arrowhead), left upper lung (thick arrow), liver, and spleen. Transaxial images show an F-18 FDG-avid mass in both ethmoid sinus (B). The scan shows intense F-18 FDG radiotracer uptake in left upper lung and uptake in the liver and spleen (CT showed no lesions), suggesting malignancy (C–D). Finally, after the PET/CT scan was done, the patient’s staging was changed from II to IV.
IBA celebrates sale of the 100th Cyclone Kiube cyclotron
By AuntMinnie.com staff writers
Ion Beam Applications (IBA) is celebrating the sale of the 100th Cyclone Kiube cyclotron.
December 21, 2023
Iba Astro 2019
Lymphoscintigraphy underused in the U.S. to diagnose lymphedema
By Will Morton
Lymphoscintigraphy is recommended but seldom used to diagnose lymphedema in real-world settings in the U.S.
December 19, 2023
Drop
New portable PET scanner tested in humans
By Will Morton
Brain imaging with a newly developed portable PET scanner appears feasible, with a comparison to conventional PET imaging revealing similar results in human subjects.
December 19, 2023
A visual abstract describing a comparison between a portable PET scanner and standard PET scanner. Image courtesy of the Journal of Nuclear Medicine.
PET/CT shows impact of different COVID-19 vaccines
By Will Morton
The type of COVID-19 vaccine and the time interval between vaccination and PET/CT scans are key factors in minimizing false interpretations in cancer patients.
December 13, 2023
A 73-year-old woman with a suspicious lung nodule was referred to our division for F-18 FDG PET/CT exam. She was vaccinated four days before PET/CT. The lung nodule did not show any pathological FDG uptake; however, high tracer activity was detected on her right arm, where she was injected, and multiple hypermetabolic lymph nodes in the right axilla (arrows). Moreover, PET/CT showed high tracer activity in the liver (black arrows), spleen (triangular arrows), and bone marrow (small triangular arrows) as the result of systemic immune response after vaccination. The tracer defect in the liver was due to the known cyst. (A) fusion scan, (B) PET, (C) maximum intensity projection. Image courtesy of Scientific Reports.
PET/MRI reveals separate Alzheimer’s biomarkers in single scan
By Will Morton
A PET radiotracer for diagnosing Alzheimer’s disease may also be used to measure vascular brain changes in patients during PET/MRI scans.
December 12, 2023
A visual abstract of a study exploring early-frame F-18 florbetaben PET/MRI for quantifying cerebral blood flow in patients with cognitive impairment. Image courtesy of the Journal of Nuclear Medicine.
AI predicts responses in patients with prostate cancer
By Will Morton
An AI model based on F-18 DCFPyL PSMA-PET/CT images shows promise for predicting treatment response in patients with metastatic castration-resistant prostate cancer.
December 12, 2023
Prostate Cancer
Study: Ditch the contrast agent in PET/MRI scans in children
By Will Morton
F-18 FDG-PET/MRI scans without the use of a contrast agent should be the top choice for imaging children suffering from lymphoma.
December 7, 2023
Pet Children
Video from RSNA 2023: Radiologists and theranostics
Eliot Siegel, MD, discusses the rapidly emerging area of theranostics and the potential for interventional molecular radiology to join diagnostic radiology and interventional radiology as a third radiology pathway for residents and trainees.
November 30, 2023
2023 11 30 Rsna Siegel Eliot
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