Molecular Imaging: Page 3

PET lung scan times could be cut by half
By Will Morton
Dynamic PET scans acquired in half the time of normal scans appear clinically feasible for patients with lung lesions.
March 6, 2024
A 60-year-old male patient with clinical suspicion of lung cancer. PET/CT scan showed FDG-avid pulmonary nodules in the upper lobe of the left lung (red arrow), with a size of 2.2 × 1.3 cm, SUVmax of 12.2, Ki-65 min of 0.016 ml/g/min, and Ki-30 min of 0.014 ml/g/min. Surgical pathology confirmed a granulomatous lesion. In addition, PET/CT scan showed many FDG-avid lung nodules in the mediastinum. (A, static PET maximum intensity projection; B, static PET SUV image; C, static PET/CT fusion image; D, dynamic PET Ki-65 min image; E, dynamic PET Ki-30 min image). Image courtesy of EJNMMI Physics.
Is ā€˜theragnomicsā€™ the future in molecular imaging?
By Will Morton
Combining theranostics and radiomics ā€“ a new concept termed ā€œtheragnomicsā€ ā€“ could be the key to realizing the full potential of molecular imaging of cancer patients.
March 6, 2024
Molecular Imaging
PET links impaired sleep in Alzheimerā€™s disease patients to tau protein
By Will Morton
PET scans have revealed specific brain pathology that may drive sleep disturbances in patients with Alzheimerā€™s disease.
February 13, 2024
A Dpatient
PET reveals brainā€™s energy demands during walking
By Will Morton
A group in England has established PET imaging as a new approach for studying gait ā€“ an excellent indicator of physical, emotional, and mental health.
February 9, 2024
Data analysis validation. Panel A: Image and line profile through the bottle on scans 1 (top) and 2 (middle), and the difference image (bottom) calculated according to Equation 3. Panel B: Data from a representative participant showing the effect of the dose correction on the PETWALK image using Equation 1 when applied to co-registered images in native subject space. The images were then warped to standard Montreal Neurological Institute (MNI) space Top: PETSTAND, middle – uncorrected PETWALK, bottom – corrected PETWALK. The color bar shows image intensity across the three images. Image courtesy of NeuroImage.
FAPI-PET shows promise in head and neck cancer patients
By Will Morton
In a comparative imaging trial, FAPI-PET/CT outperformed FDG-PET/CT in detecting primary tumors in patients with head and neck cancer.
January 26, 2024
PET/CT and MR images of a 72-year-old woman. (A) F-18 FDG-PET images (left and top) and PET/CT images (bottom) shown in coronal, sagittal, and axial views (from left to right), demonstrated a metastatic lymph node of the right neck with intensive metabolic activity (black arrow, SUVmax, 30.1) but presented no evidence for primary tumor. (B) Ga-68 FAPI-PET images (top and right) and PET/CT images (bottom), shown in axial, sagittal, and coronal views (from left to right), also detected metastatic lymph node with high Ga-68 FAPI tracer activity (black arrow, SUVmax, 16.3). There was intensive uptake of Ga-68 FAPI in palate (red arrow, SUVmax, 11.3). (C) T1-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI also presented no evidence for primary tumor. Subsequent surgery confirmed mucoepidermoid carcinoma of palate. Image courtesy of the Journal of Nuclear Medicine.
Neiman HPI publishes advanced imaging prediction index
By Kate Madden Yee
The Harvey L. Neiman Health Policy Institute (HPI) has developed and released a comorbidity index designed to help predict use of advanced imaging.
January 25, 2024
2018 08 14 19 14 9213 Neiman Hip 400
PET/CT improves diagnostic biopsy rates in lung cancer patients
By Will Morton
PET/CT imaging can serve as a metabolic guide to increase the accuracy of needle biopsies in patients with suspicious lung nodules.
January 22, 2024
Patient with extensive lung and pleural disease. (2a) The PET/CT was available prior to the biopsy showing heterogeneous F-18 FDG radiotracer uptake and delineating the most accessible area of increased metabolic activity. (2b) The biopsy was targeted to the area of increased activity area and was positive for malignant diagnosis. Image courtesy of the European Journal of Radiology.
PET/CT scans show value in patients with rare type of pancreatitis
By Will Morton
F-18 FDG-PET/CT scans may help predict relapses in patients with autoimmune pancreatitis.
January 19, 2024
F-18 FDG-PET/CT images of patients. (A) Image of a 61-year-old male patient with type 1 autoimmune pancreatitis (AIP) demonstrating diffuse enlargement of the pancreas (arrows). The serum IgG4 level was 2,260.0 mg/dL, and the TLG2.5 was 413.8 g/ml×cm3. According to the nomogram, his relapse probability is more than 95%. The patient discontinued steroid use during the maintenance phase, and 7 months later, he relapsed, with imaging showing diffuse re-enlargement of the pancreas. (B) Image of a 60-year-old male patient with type 1 AIP, showing focal enlargement in the head of the pancreas (arrows). The serum IgG4 level was 980 mg/dL, and the TLG2.5 was 92.7.0 g/ml×cm3. According to the nomogram, the patient’s relapse probability is less than 50%. After symptom relief, the patient did not receive maintenance treatment, and has been followed up for 4 years without relapse. Image courtesy of BMC Gastroenterology.
Unlocking the potential of imaging in Alzheimerā€™s disease care
By Jan Makela
In the U.S., Alzheimer's disease cases are projected to rise to nearly 13 million, making effective imaging even more crucial for early identification and effective monitoring and treatment of the condition.
January 19, 2024
Brain Puzzle Night Sky
Wider use of cardiac PET faces challenges
By Will Morton
Strategies to increase the use of cardiac PET myocardial perfusion imaging in the U.S. include education, advocacy, and industry partnerships.
January 17, 2024
Cardiac Pet
PET/MRI may help diagnose fevers of unknown origin
By Will Morton
PET/MRI imaging shows promise in diagnosing fevers or inflammation of unknown origin and may have advantages over PET/CT.
January 8, 2024
In an example image from the study, F-18 FDG-PET/MRI fusion image (A) and PET 3D image (D) show a moderately increased FDG uptake in muscles around hip joints. T2 IDEAL WATER image (B) shows increased T2 signal; LAVA WATER (C) image shows mild enhancement in these muscles. Findings were suspicious of myositis, which was histopathologically confirmed. Image courtesy of the European Journal of Radiology.
PET reveals patterns underlying cognitive decline in patients with DLB
By Will Morton
F-18 FDG-PET imaging in patients with dementia with Lewy bodies (DLB) has shown that brain hypo- and hypermetabolism may have different affects on cognition.
January 5, 2024
DLB-hypo (hypometabolic changes in dementia with Lewy bodies) was characterized by relatively reduced bilateral metabolic activity (color-coded blue) in the bilateral parietal, temporal, and occipital cortices, while DLB-hyper (hypermetabolic changes in dementia with Lewy bodies) showed relatively increased metabolic activity (color-coded red) in the cerebellum, bilateral sensorimotor, orbitofrontal, insular, and parahippocampal cortices, bilateral putamen, globus pallidum, hippocampus, and amygdala. Image courtesy of npj Parkinson’s Disease.
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