Imaging Biomarkers in Clinical Trials

Apr 24th, 2014Apr 25th, 2014
Boston, MA
US
https://ww.cme.hms.harvard.edu/courses/biomarkers
Phone:617-726-2970
Imaging biomarkers serve as important end points for clinical trials in the approval process for therapeutic drugs. Various criteria have been developed for objective interpretation of imaging studies.
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An example of a typical BgRT plan: A) PET scan on diagnostic PET/CT and B) X1 PET-Linac for patient #15 with a PET avid rib metastasis with GTV size= 3.1 cc, PTV = GTV + 5mm, BTZ (biological tracking zone) = PTV + 5 mm, AC = 14.33 kBq/mL and NTS = 21.04. Red, magenta, and green contours represent GTV, PTV, and BTZ. C) Dose distribution and D) bounded-DVH of a BgRT plan are displayed for the same patient. The bounded Dose-Volume Histogram (DVH) models variations in BgRT delivery, encompassing fluctuation in target background signal variation, target localization and dose delivery uncertainties.
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