Imaging-based Tools for Target Pharmacokinetics/Pharmacodynamics

Jan 21st, 2007Jan 23rd, 2007

Pasadena, CA

US

https://www.usc.edu/research/initiatives/bisi/

The goal of this workshop is to identify and discuss key questions regarding the development and use of dynamic, functional imaging-based tools. The workshop will include small-group discussions during which participants will have the opportunity to present their experiences to be followed by proposing ways for overcoming obstacles to progress in this field.

Emphysema progression with hole changes, with holes colored according to their diameter in 2-mm increments. (A) Baseline inspiratory nonenhanced axial CT scans in a 48-year-old man with chronic obstructive pulmonary disease show emphysema holes with hyperexpansion of secondary pulmonary lobules (white arrows) and thin alveolar walls visible in the right upper lobe. This emphysematous lesion is filled with holes of varying sizes. A single large air cyst was observed in the left upper lobe (black arrows), classified as a single emphysema hole of 20 mm or greater (bright green). (B) At six-year follow-up inspiratory nonenhanced axial CT, the holes in the right upper lobe have merged (white arrows), with no visible alveolar septa remaining, resulting in the formation of a large new hole of 20 mm or greater (bright green). Meanwhile, the hole in the left upper lobe also enlarged, merging with adjacent holes (black arrows). The size of other holes in the paramedian left upper lobe decreased.

CT reveals changes in lung holes in emphysema patients

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Emphysema progression with hole changes, with holes colored according to their diameter in 2-mm increments. (A) Baseline inspiratory nonenhanced axial CT scans in a 48-year-old man with chronic obstructive pulmonary disease show emphysema holes with hyperexpansion of secondary pulmonary lobules (white arrows) and thin alveolar walls visible in the right upper lobe. This emphysematous lesion is filled with holes of varying sizes. A single large air cyst was observed in the left upper lobe (black arrows), classified as a single emphysema hole of 20 mm or greater (bright green). (B) At six-year follow-up inspiratory nonenhanced axial CT, the holes in the right upper lobe have merged (white arrows), with no visible alveolar septa remaining, resulting in the formation of a large new hole of 20 mm or greater (bright green). Meanwhile, the hole in the left upper lobe also enlarged, merging with adjacent holes (black arrows). The size of other holes in the paramedian left upper lobe decreased.

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Pelvic (A), femoral and popliteal (B), and cruro-pedal (C) region. The summated digital variance angiography (DVA) image significantly enhances image quality compared to the digital subtraction angiography (DSA) series I–IV (depicting 4 out of 28 (A), 48 (B) and 28 (C) DSA images) of the low dose (LD) acquisitions. Enhancements of iodinated contrast medium (ICM) by DVA depict small vessel structures in detail while the conventional DSA offers a reduced contrast-to-noise ratio (CNR) using LD acquisitions for standalone diagnostic interpretations.

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