Guido Prause, PhD

2011
Computer assistance for image-based diagnosis and therapy
Attendees at this year's European Congress of Radiology were offered a preview of novel developments in image-based computer assistance for diagnosis and therapy during the Imagine Workshop. The high-tech workshop included new developments from Germany's Fraunhofer MEVIS.
March 6, 2011
2011 03 06 21 27 17 159 2011 03 07 Mevis Thumb
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Representative axial fused F-18 FDG-PET/MRI images and corresponding anatomic MRI images from a patient imaged at baseline and after initiation of androgen deprivation therapy are shown. Each row displays a distinct vascular territory. White arrows indicate focal areas of increased tracer uptake within the arterial wall, where spherical volumes of interest (VOIs) were placed for maximum standardized uptake value (SUVmax) measurement. Additional VOIs were placed in the superior vena cava and inferior vena cava for blood-pool activity sampling. SUVmax values from the arterial VOIs were extracted on the corresponding PET images and normalized to the blood-pool mean standardized uptake value to derive the maximum target-to-background ratio.
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Representative axial fused F-18 FDG-PET/MRI images and corresponding anatomic MRI images from a patient imaged at baseline and after initiation of androgen deprivation therapy are shown. Each row displays a distinct vascular territory. White arrows indicate focal areas of increased tracer uptake within the arterial wall, where spherical volumes of interest (VOIs) were placed for maximum standardized uptake value (SUVmax) measurement. Additional VOIs were placed in the superior vena cava and inferior vena cava for blood-pool activity sampling. SUVmax values from the arterial VOIs were extracted on the corresponding PET images and normalized to the blood-pool mean standardized uptake value to derive the maximum target-to-background ratio.
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Representative cardiac MRI strain images and analysis. Images in the two-, four-, and three-chamber views for strain analysis (left) and left ventricular global longitudinal strain (GLS) and global early diastolic longitudinal strain rate (eGLSR) curves (right) are shown. (A) Example images and GLS and eGLSR curves in a 37-year-old male participant with diabetes mellitus (DM) without events during follow-up after cardiac MRI. (B) Example images and GLS and eGLSR curves in a 45-year-old male participant with DM who had heart failure hospitalization during follow-up after cardiac MRI. In the left images, blue represents higher myocardial strain (higher absolute values of negative strain), whereas red represents reduced strain. In the curves, blue represents GLS, whereas orange represents eGLSR. The left y-axis denotes GLS (%), the right y-axis represents eGLSR (per second), and the x-axis denotes time (milliseconds). For these strain parameters, a lower absolute value indicates more severe myocardial functional impairment; accordingly, GLS and eGLSR were more impaired in participants with events compared with those without events.
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