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I-123 MIBG–negative and F-18 MFBG–positive scans showing multiple lesions in 9-year-old male with relapsed high-risk, multiple-relapse neuroblastoma (stage IV disease) receiving chemoimmunotherapy. (A) I-123 MIBG uptake is seen in lower lumbar vertebrae (arrows). Positive uptake with F-18 MFBG PET (B; black arrows) in skull, spine, pelvic bones, femora, and left tibia (B and C; blue and white arrows). Bone marrow biopsy was positive for disease. Follow-up I-123 MIBG imaging (D; left) and spine MRI (D; right) performed six weeks later showed diffuse disease in skull and spine, corresponding to F-18 MFBG–avid sites.
PET tracer shows promise in patients with neuroblastoma
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Radiology world mourns passing of Leonard Berlin
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PET tracer shows promise in patients with neuroblastoma
By Will Morton
The PET tracer performed better than standard SPECT imaging with iodine-123 metaiodobenzylguanidine.
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I-123 MIBG–negative and F-18 MFBG–positive scans showing multiple lesions in 9-year-old male with relapsed high-risk, multiple-relapse neuroblastoma (stage IV disease) receiving chemoimmunotherapy. (A) I-123 MIBG uptake is seen in lower lumbar vertebrae (arrows). Positive uptake with F-18 MFBG PET (B; black arrows) in skull, spine, pelvic bones, femora, and left tibia (B and C; blue and white arrows). Bone marrow biopsy was positive for disease. Follow-up I-123 MIBG imaging (D; left) and spine MRI (D; right) performed six weeks later showed diffuse disease in skull and spine, corresponding to F-18 MFBG–avid sites.
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