RSNA 2005

Nov 27, 2005

Night falls on the wet sidewalks outside McCormick Place at the end of the first day of RSNA 2005.

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PET brain scans from the same individual with early signs of Alzheimer’s disease comparing two tau radiotracers: flortaucipir, shown at top, and the investigational tracer MK6240, shown at bottom. Areas of pathological tau accumulation appear in red. The MK6240 scan shows more extensive tau buildup, suggesting that this tracer may detect Alzheimer’s-related brain changes that are less visible with the standard tracer.
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PET brain scans from the same individual with early signs of Alzheimer’s disease comparing two tau radiotracers: flortaucipir, shown at top, and the investigational tracer MK6240, shown at bottom. Areas of pathological tau accumulation appear in red. The MK6240 scan shows more extensive tau buildup, suggesting that this tracer may detect Alzheimer’s-related brain changes that are less visible with the standard tracer.
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Bar graphs show mean success (blue) and confidence (orange) according to diagnostic response (lesion present or absent, shown as “present” and “absent,” respectively) and next-step decision (submit, additional tests, and consult a senior) for each group (radiologists and nonradiologists). Error bars indicate standard errors of the mean. Lesion-absent diagnoses were more prone to error and overconfidence than were lesion-present diagnoses.
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