Theragnostics inks AstraZeneca agreement

AuntMinnie.com staff writers
Sep 4, 2019

Molecular radiotherapy developer Theragnostics said it has signed an intellectual property agreement with AstraZeneca.

The agreement allows Theragnostics to develop radiotherapy based on radionuclide-labeled poly (ADP-ribose) polymerase (PARP) inhibitors, a class of oncology drugs that block the PARP enzyme, which cancer cells use in response to DNA damage.
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An example of a typical BgRT plan: A) PET scan on diagnostic PET/CT and B) X1 PET-Linac for patient #15 with a PET avid rib metastasis with GTV size= 3.1 cc, PTV = GTV + 5mm, BTZ (biological tracking zone) = PTV + 5 mm, AC = 14.33 kBq/mL and NTS = 21.04. Red, magenta, and green contours represent GTV, PTV, and BTZ. C) Dose distribution and D) bounded-DVH of a BgRT plan are displayed for the same patient. The bounded Dose-Volume Histogram (DVH) models variations in BgRT delivery, encompassing fluctuation in target background signal variation, target localization and dose delivery uncertainties.
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