NorthStar and Bayer reach Ac-225 supply deal

AuntMinnie.com staff writers
Jul 18, 2023
2018 12 11 00 02 7009 Atom Nuclear Lab 400

NorthStar Medical Isotopes will supply Bayer with the medical radioisotope actinium-225 (Ac-225).

Under the terms of the deal, NorthStar will provide Bayer with non-carrier-added Ac-225 to be used by Bayer for several of its radiopharmaceutical programs. Ac-225 is a high-energy alpha-emitting radioisotope used in clinical trials to deliver therapeutic doses of radiation to destroy cancer cells in patients.

The radioisotope will be produced at a new dedicated Ac-225 production facility at NorthStar's Beloit, WI, campus, with the first shipments planned in 2024.

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Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.
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