The group used screening breast ultrasound in 1,666 patients who had received negative mammograms at Samsung Medical Center at Sunkyunkwan University in Seoul. Patients received mammography and/or ultrasound (n = 1,522), with younger patients receiving only screening ultrasound (n = 144).
The researchers found that in this population of mammography-negative patients, they had an additional cancer detection rate of 6/1,000 patients, with a recall rate of 5.2%. Sensitivity was 60% and specificity was 95.1%. They concluded that breast ultrasound's sensitivity was low compared to mammography, but it turned in a high specificity and positive predictive value.
Screening breast ultrasound is a relatively common tool in Asia, according to study co-author Ji-young Hwang, who is now a fellow at Samsung Medical Center. But few institutions are tracking their outcomes for quality control purposes. The paper represents a relatively simple method for auditing ultrasound screening in mammographically negative women, Hwang said.