Blue Earth highlights prostate cancer preclinical results

AuntMinnie.com staff writers
Sep 10, 2023
2022 10 21 23 21 9342 Prostate Cancer 3 D Rendering 400

Blue Earth Therapeutics is highlighting results from a preclinical study evaluating the efficacy of  actinium-225 (Ac-225) rhPSMA-10.1 compared with lutetium (Lu-177) rhPSMA-10.1 for the treatment of prostate cancer.

The results were presented at the European Association of Nuclear Medicine (EANM23) in Vienna and showed that both Ac-225 rhPSMA-10.1 and Lu-177 rhPSMA-10.1 offered excellent prostate-specific membrane antigen binding, high cellular internalization, and similar lipophilicity, the company said.

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62-year-old patient with serum PSA level of 4.11 ng/mL. Prostate MRI shows lesion in left midanterior transition zone. Lesion (arrow) shows hypointensity on T2-weighted image (A), hyperintensity on high b-value DWI (B), hypointensity on ADC map (C), and focal early enhancement on dynamic contrast-enhanced image (D). Lesion was assessed as category 4 using PI-RADS version 2.1 MRI-targeted biopsy of lesion revealed prostate adenocarcinoma with ISUP grade group 2. At subsequent radical prostatectomy performed 6 months after biopsy, ISUP grade group was upgraded to 3. ISUP, International Society of Urogenital Pathology. Image courtesy of AJR.
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