ITM Isotope Technologies Munich SE (ITM) and Debiopharm have imaged the first patient in a phase I/II trial evaluating ITM-94 as a diagnostic agent for clear cell renal cell carcinoma (ccRCC).
The trial will also evaluate ITM-94's effectiveness for classifying indeterminate renal mass as either ccRCC or noncancerous. ITM-91/ITM-94 is a peptide-based theranostic pair that combines ITM-91 (Debio 0228, or Lu-177 Lu-DPI-4452) with the diagnostic agent ITM-94 (Debio 0328, or Ga-68 Ga-DPI-4452) to target carbonic anhydrase IX (CAIX).
ITM-91/ITM-94 is an investigational theranostic pair originally discovered by 3B Pharmaceuticals GmbH and now exclusively licensed to ITM, the company said.
![A 53-year-old patient (patient number four) with a recurrent pituitary adenoma with extension of a cystic component of disease to the medial temporal lobe apparent on MRI (contoured in blue), and extension of disease to the left sphenoid bone and orbital apex apparent on [68Ga]Ga-DOTA-TATE (contoured in yellow).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/04/pituitary-tumor.QGsEnyB4bU.jpg?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
