Lantheus Medical Imaging parent Lantheus Holdings and radiation therapy equipment developer RefleXion Medical have signed a development and marketing partnership to evaluate the use of Lantheus' prostate-specific membrane antigen (PSMA)-targeted PET agent piflufolastat F-18 with RefleXion's X1 biology-guided radiotherapy system.
RefleXion X1 combines PET technology with radiation therapy delivery, allowing for real-time treatment guidance using tumor biology, Lantheus said.
The agreement will be managed by a joint steering committee and will be focused on securing U.S. regulatory approval to treat patients with biology-guided radiotherapy using piflufolastat F-18.
![A 53-year-old patient (patient number four) with a recurrent pituitary adenoma with extension of a cystic component of disease to the medial temporal lobe apparent on MRI (contoured in blue), and extension of disease to the left sphenoid bone and orbital apex apparent on [68Ga]Ga-DOTA-TATE (contoured in yellow).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/04/pituitary-tumor.QGsEnyB4bU.jpg?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
