Riverain Technologies is highlighting clinical results regarding its ClearRead CT coronary artery calcium (CAC) software.
In a study performed by a team led by James Hillis, MBBS, PhD, of Mass General Brigham AI in Boston, ClearRead CT CAC showed high agreement with both the ground truth radiologists and with the paired gated cardiac exam for scoring incidental CAC on ungated CT exams. The company reported the following key findings:
- Agreement between ClearRead CT CAC and ground-truth radiologists was 96%
- Agreement between ClearRead CT CAC and paired cardiac gated CT was 90%
- ClearRead CT CAC accurately calculated Agatston scores on nongated CTs and produced similar scores to paired cardiac gated CTs
"Use of ClearRead CT CAC could broaden screening for atherosclerotic cardiovascular disease, enabling opportunistic screening on CTs captured for other indications," the company noted.
![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
