Dear AuntMinnie Insider,
Extracolonic findings are an enduring issue in virtual colonoscopy if ever there was one. In some cases nabbing an unexpected renal cancer or abdominal aortic aneurysm can save a patient's life. Other findings have little or no clinical importance, and simply add risk and costs to the VC exam when they are followed up.
In one sense the issue is VC's alone; the findings cannot be seen at optical colonoscopy. Yet the screening dilemma is all too familiar to anyone who's performed whole-body CT, or scanned smokers for lung cancer.
In a frank talk at last week's International Symposium on Virtual Colonoscopy in Boston, Dr. Mark Klein touched on the clinical, ethical, and legal issues surrounding VC's "pesky double-edged sword," weighing in with his own ideas on costs and patient management. For the rest of the story, just click on our Insider Exclusive, delivered to Virtual Colonoscopy Digital Community subscribers like you first.
Also of note are two more articles from this year's VC symposium, sponsored by the Boston University School of Medicine. In one, Dr. Perry Pickhardt shows how VC was a good "filter" for conventional colonoscopy in more than 3,000 patients. In another, noted gastroenterologist and epidemiologist Dr. David Ransohoff looks at what is known about the natural history of polyps.
You're invited to read about a state-of-the-art electronic cleansing application that goes beyond the capabilities of threshold-based algorithms for separating residual stool from mucosa. This issue also features several stories on the genetics of colorectal cancer, all available with a quick scroll through your Virtual Colonoscopy Digital Community.



















![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&fit=crop&h=112&q=70&w=112)
