NorthStar, Point Biopharma ink Ac-225 supply deal

AuntMinnie.com staff writers

Sep 7, 2021

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NorthStar Medical Radioisotopes and Point Biopharma Global have signed a supply agreement covering the development and commercialization of the medical radioisotope actinium-225 (Ac-225).

Under the deal, NorthStar will provide its electron accelerator-produced Ac-225 to Point. Point will use the radioisotope in the investigational studies of PNT2001, a prostate-specific membrane antigen (PSMA) for nonmetastatic castrate-sensitive prostate cancer and PNT2004, a fibroblast activation protein-α candidate with potential pan-cancer applications.

Also, Ac-225 will be used to advance Point's new tumor microenvironment tumor-targeting platform.

$ChatGPT powered by GPT-4 and using DALL-E−3 was asked to generate an image for teaching purposes that demonstrated: a nuclear medicine bone scan with skeletal metastases (top left); coronary artery disease (top right); an F-18 FDG-PET scan of the brain with Alzheimer's disease (bottom left); and an x-ray showing a fracture (bottom right). These are misleading for educational purposes and for patients who may be searching for information. Image and caption courtesy of Radiography.$

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Nine representative patients who underwent F-18 FDG and F-18 FAPI-74 PET imaging. F-18 FAPI-74 PET outperforms F-18 FDG-PET in detecting primary tumors (patients 11, 39, 50, 58, 79, and 101; solid black arrows), local recurrences (patient 4; blue arrows), abdomen LN metastases (patients 4 and 50; green arrows), intrahepatic metastases (patient 50; red arrows), bone metastases (patient 85; arrowheads), and peritoneal metastases (patients 4, 11, 85, 97, and 101; dotted arrows). Image courtesy of the Journal of Nuclear Medicine.

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