Molecular Insight begins phase II clinical trial

AuntMinnie.com staff writers

Mar 26, 2006

Molecular Insight Pharmaceuticals has begun a phase II clinical trial of its Zemiva molecular imaging pharmaceutical.

The trial, which is designed to include approximately 120 patients at 12 centers in North America, aims to develop a reference database of normal cardiac Zemiva images using SPECT imaging, according to the Cambridge, MA-based firm.

By AuntMinnie.com staff writers
March 27, 2006

Related Reading

MDS Nordion, Molecular Insight Pharmaceutical partner, February 16, 2006

Molecular Insight fills executive ranks, July 21, 2005

Molecular Insight hires new vice presidents, June 1, 2005

Molecular Insight raises $28 million, June 1, 2005

Molecular Insight, University of Maryland get NIH grant, August 27, 2004

Copyright © 2006 AuntMinnie.com

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Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.

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