The use of cathartic bowel preparation has been identified as the single most important reason for low patient adherence to colorectal screening. A recent study found that laxative-free CTC with CAD yields significant improvement in perceived comfort, while achieving comparable performance to optical colonoscopy and standard CTC for detecting adenomas 10 mm or larger. However, the detection performance of fully automated CAD had not been evaluated in laxative-free (noncathartic) CTC screening of asymptomatic adults, said presenter Janne Nappi, PhD, of Massachusetts General Hospital.
As a result, the researchers evaluated their CAD system, which was optimized for laxative-free CTC, in a study of more than 600 asymptomatic men and women. The CAD system yielded sensitivity and false-positive rates that are likely to be in a clinically acceptable range, Nappi said.
However, "untagged feces can limit the detection accuracy for small polyps in suboptimally prepared cases," he told AuntMinnie.com.
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