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Video from SNMMI: Phillip Kuo on new Alzheimer’s disease imaging guidelines

Will Morton, Associate Editor, AuntMinnie.com. Headshot
Will Morton
Jun 22, 2025

NEW ORLEANS -- In an interview at the Society of Nuclear Medicine and Molecular Imaging annual meeting, Phillip Kuo, MD, PhD, of the City of Hope in Duarte, CA, discussed new appropriate use criteria for amyloid and tau PET imaging in Alzheimer’s disease patients.

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(A) Overview of study participants with different clinical phenotypes depicted in distinct colors: Limbic encephalitis (LE)/temporal lobe epilepsy (TLE): Blue; cerebellar ataxia (CA): Green; stiff person syndrome (SPS): Red, including overlapping clinical features with an overview of the analyzed parameter; generated in Biorender. (B) F-18 F-DED uptake, as visualized by SUVr with global mean scaling, is shown for three representative patients with GAD65-AIE: Patient #6 with LE/TLE, showing mesiotemporal F-18 F-DED uptake; patient #16 with overlapping clinical features of CA, SPS, and LE, showing both mesiotemporal and cerebellar F-18 F-DED uptake; and patient #17 with isolated SPS showing no increased F-18 F-DED uptake. Additionally, the average F-18 F-DED uptake of eight controls is shown on the right.
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(A) Overview of study participants with different clinical phenotypes depicted in distinct colors: Limbic encephalitis (LE)/temporal lobe epilepsy (TLE): Blue; cerebellar ataxia (CA): Green; stiff person syndrome (SPS): Red, including overlapping clinical features with an overview of the analyzed parameter; generated in Biorender. (B) F-18 F-DED uptake, as visualized by SUVr with global mean scaling, is shown for three representative patients with GAD65-AIE: Patient #6 with LE/TLE, showing mesiotemporal F-18 F-DED uptake; patient #16 with overlapping clinical features of CA, SPS, and LE, showing both mesiotemporal and cerebellar F-18 F-DED uptake; and patient #17 with isolated SPS showing no increased F-18 F-DED uptake. Additionally, the average F-18 F-DED uptake of eight controls is shown on the right.
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