Cardiovascular AI software developer HeartFlow has partnered with the Boone Heart Institute in Greenwood Village, CO, to launch Gamefilm Registry, a data collection effort to define cardiac risk in retired National Football League (NFL) players.
The registry will enroll 120 retired NFL players to assess cardiovascular risks using HeartFlow’s advanced imaging and AI-powered analysis tools, such as its Fractional Flow Reserve-CT (FFR-CT) software, which uses CT scans to calculate how much blood is flowing through the coronary arteries.
Gamefilm Registry provides insights into coronary artery disease prevalence, risk factors, and treatment protocols in retired athletes, a population that faces distinct risks due to the physical demands of their careers, HeartFlow noted.
![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
