Sunday, November 29 | 11:45 a.m.-11:55 a.m. | SSA06-07 | Room E353A
Tumor volume often falls significantly after chemotherapy, but the drop in iodine uptake may be more significant for prognosis. A group from Johns Hopkins University measured treatment response using iodine uptake with dual-energy CT (DECT) before and after treatment of pancreatic cancer.The study was performed to evaluate quantitative changes in iodine uptake by pancreatic adenocarcinoma before and after chemotherapy using dual-source, dual-energy CT, lead author Dr. Satomi Kawamoto wrote in an email to AuntMinnie.com.
Patients with newly diagnosed pancreatic cancer were scanned, and tumor volume decreased in 86% of the patients after treatment. Average tumor iodine uptake fell in the arterial phase and also in the venous phase.
"Iodine uptake by pancreatic adenocarcinoma by dual-energy CT may be potentially useful for assessment of treatment response," Kawamoto wrote.
![Images show the pectoralis muscles of a healthy male individual who never smoked (age, 66 years; height, 178 cm; body mass index [BMI, calculated as weight in kilograms divided by height in meters squared], 28.4; number of cigarette pack-years, 0; forced expiratory volume in 1 second [FEV1], 97.6% predicted; FEV1: forced vital capacity [FVC] ratio, 0.71; pectoralis muscle area [PMA], 59.4 cm2; pectoralis muscle volume [PMV], 764 cm3) and a male individual with a smoking history and chronic obstructive pulmonary disorder (COPD) (age, 66 years; height, 178 cm; BMI, 27.5; number of cigarette pack-years, 43.2, FEV1, 48% predicted; FEV1:FVC, 0.56; PMA, 35 cm2; PMV, 480.8 cm3) from the Canadian Cohort Obstructive Lung Disease (i.e., CanCOLD) study. The CT image is shown in the axial plane. The PMV is automatically extracted using the developed deep learning model and overlayed onto the lungs for visual clarity.](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/03/genkin.25LqljVF0y.jpg?auto=format%2Ccompress&crop=focalpoint&dpr=2&fit=crop&h=167&q=70&w=250)
