Sunday, November 29 | 11:45 a.m.-11:55 a.m. | SSA06-07 | Room E353A
Tumor volume often falls significantly after chemotherapy, but the drop in iodine uptake may be more significant for prognosis. A group from Johns Hopkins University measured treatment response using iodine uptake with dual-energy CT (DECT) before and after treatment of pancreatic cancer.The study was performed to evaluate quantitative changes in iodine uptake by pancreatic adenocarcinoma before and after chemotherapy using dual-source, dual-energy CT, lead author Dr. Satomi Kawamoto wrote in an email to AuntMinnie.com.
Patients with newly diagnosed pancreatic cancer were scanned, and tumor volume decreased in 86% of the patients after treatment. Average tumor iodine uptake fell in the arterial phase and also in the venous phase.
"Iodine uptake by pancreatic adenocarcinoma by dual-energy CT may be potentially useful for assessment of treatment response," Kawamoto wrote.
![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
