USPSTF would like to determine whether incorporating three risk factors -- beyond the traditional two currently used, the Pooled Cohort Equations tool and the Framingham risk model -- could potentially improve health outcomes. To that end, the task force is looking for research on incorporating ankle-brachial index (ABI), coronary artery calcium (CAC), and high-sensitivity C-reactive protein (CRP) into the standard cardiovascular risk assessment.
In its public comments, USPSTF is asking for information on five questions:
- Compared with the Pooled Cohort Equations tool or Framingham risk factors alone, does risk assessment of asymptomatic adults using nontraditional risk factors lead to reduced incidence of cardiovascular events and/or mortality?
- Does the use of nontraditional risk factors in addition to traditional risk factors to predict cardiovascular disease risk improve measures of calibration, discrimination, and risk reclassification?
- What are the harms of nontraditional risk factor assessment?
- Does treatment guided by nontraditional risk factors in addition to traditional risk factors lead to reduced incidence of cardiovascular events and/or mortality?
- What are the harms of aggressive risk factor modification?
Respondents have until 8 p.m. EST on July 8 to comment on the proposed research plan.
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