The National Institutes of Health (NIH) with the NIH Common Fund plans to invest in an AI project that will integrate clinical imaging with other health data types to create clinical decision support (CDS) tools.
Called Precision Medicine with Artificial Intelligence-Integrating Imaging with Multimodal Data (PRIMED-AI), the program seeks to accelerate translation of AI-enabled, image-based, multimodal CDS tools into practical clinical use, according to the NIH.
One of PRIMED-AI's objectives is a "playbook initiative" that involves developing and testing discrete projects that deliver frameworks for responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology and linkage, and preparation for regulatory approval.
Further, the project aims to generate a validation framework for rigorous, impartial assessment of the overall dependability of AI models developed across the PRIMED-AI ecosystem and beyond.
PRIMED-AI is in its early stages, and a notice of funding (UG3) opportunity is coming, NIH said in a September update. Investigators with expertise and insights into AI-driven integration of clinical imaging with other complex and multiscale health data are encouraged to consider applying.
Find more information here.















![A normal mammogram confirmed by three-year radiologic follow-up illustrates reader-marked regions of interest (ROIs) during (A) unaided (round 1) and (B) artificial intelligence (AI)–assisted (round 2) reading. Each colored dot represents an ROI for recall by a human reader. Readers could mark more than one ROI per case, represented by multiple dots of the same color. During AI-assisted reading, the AI system displayed three visible prompts: two with suspicion of malignancy scores of 35% (left mediolateral oblique [L MLO] and craniocaudal [L CC]) and one with a suspicion of malignancy score of 10% (right craniocaudal [R CC]), shown as polygonal overlays. Without AI, six of 10 readers (60%) marked a false-positive ROI. With AI assistance, this fell to two of 10 (20%). R MLO = right mediolateral oblique.](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/07/2026-07-14-radiology-mammogram-ai-auto-bias.H0bYO8QlWs.jpg?auto=format%2Ccompress&fit=crop&h=112&q=70&w=112)



