Diana Roettger, PhD, and Olga Kubassova, PhD

MRI
Advanced imaging offers insight into targeted therapies
Major breakthroughs are emerging in the development of targeted therapies that use the body's own immune system to attack cancer cells. But traditional methods of measuring the success of drug candidates are slow and expensive. Could advanced imaging help? Diana Roettger, PhD, and Olga Kubassova, PhD, of the Image Analysis Group offer a perspective.
February 5, 2019
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Digital X-Ray
Most DCIS sizes are either over- or underestimated on x-ray
More than two out of three ductal DCIS sizes are radiologically either over- or underestimated on x-ray imaging.
Post-Pluvicto SPECT/CT with axial fused images of sacrum and sagittal maximum intensity projection of one of the patients who complained of increasing pain in the sacral region (arrows) post therapy.
Nuclear Medicine
What side effects do patients report after Pluvicto therapy?
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Molecular Imaging
Brain SPECT offers insight into suicide risk
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Women's Imaging MinnieCast, Episode 10: To treat or not to treat DCIS?
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Most DCIS sizes are either over- or underestimated on x-ray
By Amerigo Allegretto
More than two out of three ductal DCIS sizes are radiologically either over- or underestimated on x-ray imaging.
June 5, 2026
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What side effects do patients report after Pluvicto therapy?
By Will Morton
Fatigue, pain flare, nausea, and urinary symptoms are among the most commonly reported immediate side effects of Pluvicto therapy.
June 5, 2026
Post-Pluvicto SPECT/CT with axial fused images of sacrum and sagittal maximum intensity projection of one of the patients who complained of increasing pain in the sacral region (arrows) post therapy.
Brain SPECT offers insight into suicide risk
By Kate Madden Yee
Study results show that a single resting-state scan yields individualized risk trajectories that identify high-risk patients.
June 5, 2026
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Lars Grimm, MD, discusses challenges in DCIS care and his work in the COMET study.
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The study confirms that deficits in M1 receptor are present in a subgroup of schizophrenia patients.
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MRI finds perfusion defects across a range of lung impairments
By Kate Madden Yee
Impaired lung function is associated with increased pulmonary perfusion defects detectable by a particular MRI technique.
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Caption: Representative images show emphysema and functional lung maps derived by CT and PREFUL-MRI: (A–C) CT-derived emphysema images, (D–F) perfusion maps, (G–I) regional ventilation maps, (J–L) flow-volume loop correlation metric maps, (M–O) ventilation/perfusion combined parameter maps. (A, D, G, J, M) Images in a 63-year-old male with normal spirometry: FEV1%pred = 89.0%, FEV1/FVC = 0.73; emphysema percentage = 0.2%, QDP = 7%, VDPRVent = 2%, VDPFVL-CM = 1%. (B, E, H, K, N) Images in a 65-year-old female with PRISm + RP: FEV1%pred = 71.2%, FVC %pred = 76.8%, FEV1/FVC = 0.76; emphysema percentage = 4.7%, QDP = 10%, VD-PRVent = 18%, VDPFVL-CM = 6%. (C, F, I, L, O) Images in a 57-year-old male with AO: FEV1%pred = 56.8%, FEV1/FVC = 0.52; emphysema = 11.1%, QDP = 31%, VDPRVent = 33%, VDPFVL-CM = 41%. AO = airflow obstruction, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, FVL-CM = flow-volume loop correlation metric, %pred = percent predicted, PREFUL = phase-resolved function lung, PRISm = preserved ratio impaired spirometry, QDP = perfusion defect percentage, RVent = regional ventilation, VDP = ventilation defect percentage.
AI detects lung cancer nodules well but shows low specificity
By Kate Madden Yee
The finding suggests the models offer “a potential role as adjunctive tools for ruling out malignancy” rather than classifying it.
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RMTA lays out radiopharmaceutical regulatory and payment policy issues.
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The algorithm could offer a “practical alternative in cardiac PET,” researchers noted.
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Cardiac stress test imaging comparison showing DeepAC and CT-based attenuation correction scans for two patients with quantitative perfusion data.
Image-guided focal laser ablation effective for prostate cancer
By Amerigo Allegretto
MRI-directed, ultrasound-guided TPLA may be a promising technique to treat prostate cancer while avoiding radical therapies.
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Preablation, postablation, and recurrence multiparametric MRI scans depict a 63-year-old man treated with transperineal focal laser ablation (TPLA) for localized prostate cancer. Clinical parameters included an initial prostate-specific antigen (PSA) level of 7.2 ng/mL, a Prostate Imaging Reporting and Data System (PI-RADS) grade 4 lesion (red circles) in the right apical peripheral zone, and a maximum tumor length of 5 mm. MRI-guided targeted biopsy confirmed a Gleason score 3+4 prostate cancer tumor. (A) Pre-ablation axial T2-weighted MRI scan and apparent diffusion coefficient (ADC) image shows the apical PI-RADS 4 lesion (circles). (B) Six-month post-ablation axial T2-weighted MRI scan and ADC image show cystic necrosis (arrows). There was no evidence of recurrence; the PSA level was 1.5 ng/mL. (C) One-year after ablation, the patient’s PSA level had increased to 4.3 ng/mL. Axial T2-weighted MRI scan and the ADC image shows a recurrent lesion (blue circles) in the right apical peripheral zone adjacent to the ablation scar. Targeted biopsy confirmed Gleason score 3+4 prostate cancer, which was classified as in-field recurrence of clinically significant prostate cancer and subsequently re-treated with TPLA. In summary, serial multiplanar MRI demonstrates treatment response after TPLA with post-ablation necrosis, followed by MRI-detected IFR confirmed with biopsy at 12-month follow-up. Multiparametric MRI was performed with a 3.0-T MRI scanner (Skyra; Siemens Healthineers) using T2-weighted, diffusion-weighted, and ADC sequences, with gadobenate dimeglumine contrast material administration (Bracco Diagnostics).
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Screening rate increased sharply over six years at the 17-hospital health system.
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Philips Interactive Multimedia Reporting: Where Insight Meets Impact
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Radiology is no longer just about what you see, it’s about how effectively you communicate it.
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