Molecular Imaging: Page 25

FAPI-PET bests FDG-PET in detecting gastrointestinal cancer

Fibroblast activation protein inhibitor (FAPI)-PET/CT appears superior to standard FDG-PET/CT for detecting gastrointestinal cancer.

October 31, 2023

Nine representative patients who underwent F-18 FDG and F-18 FAPI-74 PET imaging. F-18 FAPI-74 PET outperforms F-18 FDG-PET in detecting primary tumors (patients 11, 39, 50, 58, 79, and 101; solid black arrows), local recurrences (patient 4; blue arrows), abdomen LN metastases (patients 4 and 50; green arrows), intrahepatic metastases (patient 50; red arrows), bone metastases (patient 85; arrowheads), and peritoneal metastases (patients 4, 11, 85, 97, and 101; dotted arrows). Image courtesy of the Journal of Nuclear Medicine.

PET brain study: More research needed in former NFL players

PET imaging shows high levels of brain protein activity associated with injury in a large group of young, former National Football League (NFL) players.

October 30, 2023

Mean parametric maps of carbon-11 (C-11) DPA-713 radiotracer binding (VT) are presented in three views for each group (NFL, control) within each TSPO genotype (C/C, C/T). VT indicates total distribution volume and is in units of milliliters per cubic centimeter (mL/cm3). Image courtesy of JAMA Network Open.

PET/MRI reveals effects of COVID-19 vaccines in children

PET/MRI scans have revealed immune system reactions after COVID-19 vaccines in children with cancer.

October 30, 2023

A graphic abstract describing the study. Image courtesy of the Journal of Nuclear Medicine.

PET reveals patient responses to new Alzheimer’s disease drug

Patients with less tau pathology on PET scans may respond better to treatment with the new Alzheimer’s disease drug donanemab.

October 27, 2023

Bone scans may be viable for diagnosing calciphylaxis

Technetium-99m methyl diphosphonate bone scans are a potentially viable noninvasive option for diagnosing calciphylaxis.

October 25, 2023

Pediatric PET radiotracer doses drop by a third over two decades

Over the past 20 years, children have benefited from a massive reduction in PET imaging radiotracer doses without compromise in image quality.

October 20, 2023

Researchers offer hypothesis for long COVID brain fog

A group in France has offered an explanation for long COVID brain fog, with the concept based on a visual brain pattern they discovered on patient PET scans.

October 19, 2023

Hypometabolism detected with F-18 FDG-PET in long-COVID patients: putative astrocyte dysfunction and glutamatergic dysregulation. (A) PET scan of a healthy subject. (B) PET scan of a long COVID patient. Hypometabolic areas are indicated with arrows. (C) A diagram showing a healthy condition in which an astrocyte has a normal capacity to take up glutamate and recycle it to sustain glutamatergic neurotransmission, giving rise to normal glucose utilization and lactate production to ensure adequate neuronal energy supply. (D) A diagram showing a long COVID condition in which an astrocyte has reduced glutamate uptake capacity, leading to reduced glutamate recycling, lower glucose utilization (observed with F-18 FDG-PET as hypometabolism) and lower lactate production, dysregulating glutamatergic neurotransmission, and possibly endangering neuronal survival.

PET/CT radiomics may improve diagnosis of VCFs

A PET/CT-based radiomics approach could help clinicians distinguish between malignant and benign vertebral compression fractures (VCFs).

October 17, 2023

PET tracer targets KRAS mutations in cancer patients

A group in China has developed a PET radiotracer that visualizes tumors with KRAS mutations in patients with lung and colon cancer.

October 16, 2023

Representative F-18 PFPMD-PET/CT images of non-KRAS-G12C and KRAS-G12C tumors in patients with non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). Image courtesy of the Journal of Nuclear Medicine.

CMS lifts limit on amyloid PET coverage

CMS has lifted its coverage limit of one amyloid PET scan per lifetime for patients with Alzheimer’s disease.

October 13, 2023

TRIGA reactor fuel supply restored in the U.S

Pennsylvania State University has received the first TRIGA nuclear research reactor fuel delivery in the U.S. in a decade.

October 12, 2023

Penn State received the TRIGA reactor fuel on September 27.

PET study questions equity of NFL’s concussion settlement

PET brain scans of former NFL players with dementia due to repetitive head impacts do not show typical signs of Alzheimer’s disease.

October 10, 2023

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