Lantheus reports data from cardiac PET trial

Lantheus Medical Imaging of North Billerica, MA, reported results from a phase I clinical trial of a new cardiac PET radiopharmaceutical at this week's SNM meeting in New Orleans.

The company is researching BMS747158, a fluorine-18-based PET agent for myocardial perfusion. The firm said that data from the safety and tolerability study of the agent presented at the SNM show indicate that BMS747158 has a "favorable radiation dosimetry profile and is generally well-tolerated." In addition, the research showed "high myocardial uptake that was stable over time with favorable myocardial to background ratios."

Lantheus believes that BMS747158 could serve as a new class of PET agents for myocardial perfusion imaging. The radiopharmaceutical has "high, rapid, and sustained cardiac uptake proportional to blood flow, slower washout, higher target to nontarget uptake ratios, ability to image perfusion deficits, and capability to produce high quality of images taken in multiple species compared to currently marketed tracers," the company said.

The research presented this week was conducted by Dr. Jamshid Maddahi of the David Geffen School of Medicine at the University of California, Los Angeles.

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Lantheus focuses on cardiac imaging following BMS spinoff, March 27, 2008

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