Sunday, November 29 | 11:05 a.m.-11:15 a.m. | SSA04-03 | Room S404CD
The rise of CT lung cancer screening has been accompanied by a few published lung nodule scoring systems, including Lung-RADS and the McWilliams model. But could the models be tweaked to perform better?Researchers from the Netherlands will explore the possibilities in this Sunday session.
"Lung cancer screening is an important topic and has gained a lot of interest," presenter Dr. Sarah van Riel, from Radboud University Medical Center in Nijmegen, the Netherlands, told AuntMinnie.com. "In the past couple of years, various scoring systems for screen-detected nodules have been published. In our study, we were interested in comparing the performance of two well-described scoring systems to each other."
The researchers reviewed 60 cancers from the Danish Lung Cancer Screening Trial, along with a set of 120 randomly selected benign nodules of various sizes, all from different screening subjects. Seven readers scored morphological features for each nodule that referred to density distribution, lesion margins, lesion surroundings, and lesion architecture.
They found significant differences related to inhomogeneous density distribution and pleural/fissure retraction among the readers. Several morphological features are significantly associated with nodule malignancy but are not included in published risk-prediction models, the team concluded.
![Axial images from unenhanced calcium score cardiac CT (left) and curved planar reformation images from CT angiography (right) show that higher long-term exposure to air pollution is associated with greater coronary artery calcium and more obstructive coronary artery disease (CAD). Top row: Images in a 68-year-old male patient with higher 10-year mean ambient air pollution exposure (7.9 μg/m3 for particulate matter measuring ≤2.5 μm in diameter [PM2.5] and 17.4 parts per billion [ppb] for NO2) with extensive CAD (coronary artery calcium score [CACS] >1,000 and obstructive CAD [≥70% diameter stenosis]). Bottom row: Images in a 57-year-old female patient with lower 10-year mean ambient air pollution exposure (6.3 μg/m3 for PM2.5 and 4.6 ppb for NO2) with no CAD (CACS = 0 and no obstructive stenosis).](https://img.auntminnie.com/mindful/smg/workspaces/default/uploads/2026/06/hanneman.r6SMLzkezo.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
