Theragnostics, German hospital to study THG-008 for PET

AuntMinnie.com staff writers

Feb 16, 2021

2017 09 14 23 05 1167 Cancer Cell 400

Theragnostics and Essen University Hospital in Germany will study the investigational agent THG-008 for use in PET imaging of a range of cancers.

The research on the novel F-18 radiolabeled poly (ADP-ribose) polymerase (PARP) inhibitor THG-008 is expected to begin in February 2021. Evidence has already shown that the agent can be used for imaging head and neck cancer. It can detect primary and metastatic head and neck squamous cell carcinoma lesions, and retention in cancer deposits was longer than in healthy tissues.

Group mean C-11 PBR28 SUVR maps of females with ASD (top) and female controls (middle). Statistical map from voxelwise comparison of C-11 PBR28 SUVR between groups, controlled for age and TSPO genotype, shows elevated regional TSPO levels relative to whole brain mean in the midcingulate cortex and splenium of the corpus callosum in ASD (N = 12) compared with controls (N = 10) (Z > 2.3, pcluster) (bottom). TSPO = translocator protein, ASD = autism spectrum disorder, CON = control, SUVR = standardized uptake value ratio, N = number. Image and caption courtesy of Neuropsychopharmacology.

PET/MRI reveals sex differences in patients with autism

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Driving the future of PET/CT.

Driving the future of PET/CT.

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Predictions and Grad-CAMs of ViT-based models on sample PET/CT, PET, and CT test images from the “positive” class. ViT was fine-tuned using training data for each modality. The bounding boxes depicted in the figure indicate malignant lesions. The top row of the Grad-CAMs shows important areas for “positive” predictions, and the bottom row shows areas for “negative” predictions. Image courtesy of Scientific Reports.

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PET/MRI reveals sex differences in patients with autism

PET/MRI shows that young women with autism spectrum disorder have increased brain metabolism associated with translocator protein (TSPO).

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Group mean C-11 PBR28 SUVR maps of females with ASD (top) and female controls (middle). Statistical map from voxelwise comparison of C-11 PBR28 SUVR between groups, controlled for age and TSPO genotype, shows elevated regional TSPO levels relative to whole brain mean in the midcingulate cortex and splenium of the corpus callosum in ASD (N = 12) compared with controls (N = 10) (Z > 2.3, pcluster) (bottom). TSPO = translocator protein, ASD = autism spectrum disorder, CON = control, SUVR = standardized uptake value ratio, N = number. Image and caption courtesy of Neuropsychopharmacology.

PET tracer for gliomas under expedited review

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F-18 FDG and Ga-68 FAPI-46 images of a 51-year-old woman with adenocarcinoma with lepidic growth pattern in right upper lobe. (A) Maximum-intensity-projection PET images. The lesion had F-18 FDG uptake below blood pool level but was strongly Ga-68 FAPI-46-positive. CT-guided biopsy led to pathologic diagnosis of adenocarcinoma, and the patient was treated by stereotactic body radiation therapy because of functional inoperability. Image courtesy of the Journal of Nuclear Medicine.

Vision transformer AI model boosts PET/CT imaging of cancer

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Predictions and Grad-CAMs of ViT-based models on sample PET/CT, PET, and CT test images from the “positive” class. ViT was fine-tuned using training data for each modality. The bounding boxes depicted in the figure indicate malignant lesions. The top row of the Grad-CAMs shows important areas for “positive” predictions, and the bottom row shows areas for “negative” predictions. Image courtesy of Scientific Reports.

Can AI improve sustainability in nuclear medicine?

Nuclear medicine experts support the use of AI to improve sustainability of practices in the field, yet say implementation will require careful consideration of the technology’s benefits and detriments.

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ChatGPT powered by GPT-4 and using DALL-E−3 was asked to generate an image for teaching purposes that demonstrated: a nuclear medicine bone scan with skeletal metastases (top left); coronary artery disease (top right); an F-18 FDG-PET scan of the brain with Alzheimer's disease (bottom left); and an x-ray showing a fracture (bottom right). These are misleading for educational purposes and for patients who may be searching for information. Image and caption courtesy of Radiography.

PET/MRI detects brain injury in pediatric cancer survivors

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A visual abstract of the study. Image courtesy of the Journal of Nuclear Medicine.

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Life Molecular Imaging and Sofie Biosciences have begun offering the Neuraceq PET radiotracer produced at Sofie's radiopharmaceutical manufacturing site in Cleveland, Ohio.

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The company said the mobile trailer complements its other services, which include PET/CT buildouts and on-demand daily use rubidium-82 radioisotope services.

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The rise of theranostics: Part 2 -- Moving into communities

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Theranostics with Thomas Hope, MD, University of California, San Francisco (UCSF)

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A visual abstract of the study by the authors. Image courtesy of the Journal of Nuclear Medicine.

SNMMI to tackle Capitol Hill

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The Society of Nuclear Medicine and Molecular Imaging (SNMMI) will host its annual Hill Day on April 5 in Washington, DC.

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PET/MRI may improve diagnosis of Cushing disease

PET/MRI could become the diagnostic method of choice over MRI alone for identifying small pituitary tumors associated with Cushing disease.

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T1-weighted postgadolinium MR images (A and C) and F-18 FET-PET/MR images (B and D) centered at pituitary before (A and B) and after (C and D) transsphenoidal surgery. This patient with Cushing disease showed clear focal uptake (B) but no clear lesion on previously obtained and accompanying MRI (A). Postoperative tissue analysis did confirm resection of small pituitary adenoma/PitNET, and postoperative F-18 FET-PET showed no residual uptake (D). Image courtesy of the Journal of Nuclear Medicine.

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