Lantheus to discuss PyL imaging agent at SNMMI 2020

AuntMinnie.com staff writers

Jun 30, 2020

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Lantheus Medical Imaging will showcase the potential of its PyL (F-18 DCFPyL) radiopharmaceutical at the virtual Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2020 annual meeting, July 11-14.

PyL is an investigational prostate-specific membrane antigen-targeted small-molecule PET radiopharmaceutical that aims to visualize prostate cancer. Data from company-sponsored studies of PyL will be presented on July 11 in the Science Pavilion at SNMMI 2020.

The information that will be presented evaluates the diagnostic performance and clinical impact of PyL in patients with biochemical recurrence of prostate cancer. Another abstract focuses on a digital solution Latheus is developing with PyL in the hopes of supporting prostate cancer staging with the use of the automated miPSMA index of the PET/CT PyL-prostate specific membrane antigen (PSMA) images.

Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.

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Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.

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