By Wayne Forrest, AuntMinnie.com staff writer

May 30, 2017 -- Researchers from the Mayo Clinic in Rochester, MN, have confirmed the presence of gadolinium deposits in postmortem brain tissue of pediatric patients with normal renal function who underwent contrast-enhanced MRI scans, according to a study published online May 22 in JAMA Pediatrics.

The findings mirror other studies that have found gadolinium in the brains of adult patients with normal kidney function years after they received gadolinium-based contrast agents (GBCAs). The detection in pediatric patients may be of greater concern, however, because their brains are still developing and they are more susceptible to the neurotoxic effects of heavy metal exposure.

"Although our data are limited by small sample size, the deposition appears to follow a dose-dependent trend with preferential accumulation in the dentate and deep gray nuclei, similar to what has been described in the adult population," wrote lead author Jennifer McDonald, PhD, and colleagues (JAMA Pediatr, May 22, 2017).

Approximately 40% of the 3 million pediatric MRI scans in the U.S. every year use gadolinium contrast, the authors wrote. Despite this prevalence, previous studies on the potential effects of single or repeated GBCA administration have focused on adults.

That may be changing. Earlier this year, German researchers found that the use of a macrocyclic GBCA for MRI scans did not increase signal intensity in the dentate nucleus in pediatric patients. The results were also consistent with a previous study of adult patients.

In the current single-center, retrospective, case-control study, McDonald and colleagues analyzed postmortem brain tissue from three pediatric patients who died between 2000 and 2015. The subjects had undergone at least four MRI scans with gadodiamide (Omniscan, GE Healthcare) during their lifetime. Their samples were compared with those from a control group of three pediatric patients who had never received gadolinium-enhanced MRI.

The researchers detected gadolinium in all four neuroanatomic regions -- the dentate nucleus, pons, globus pallidus, and thalamus -- in the three subjects who had received contrast. The highest concentrations of gadolinium were in the dentate nucleus or pons. No gadolinium was found in the postmortem brain tissue of the three control subjects.

Given that pediatric brains are more susceptible to heavy metal exposure, additional research is essential, along with "more judicious use of gadolinium contrast in the pediatric population," the group concluded.

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Last Updated np 5/26/2017 2:16:14 PM

15 comments so far ...
5/31/2017 5:08:31 AM
Free Bird
This upsets me so but comes as no surprise. The FDA is letting this happen and should put a stop to gadolinium based contrast agents. They know the outcome, the Pharmaceutical Companies know the outcome. This is a Toxic Heavy Metal they are injecting in the Body and it deposits. They all know it causes a multitude of symptoms, impacts the body negatively and even death. This is criminal.  It is a World Wide Problem. 
They find these deposits in the Brains of Dead Children/Adults. There is no publication of the Symptoms, Illnesses or the Cause of death on these Children/People. I hope somebody of importance is reading this and will do research on this.  The question stands was it Gadolinium that caused their demise in the end? 
Thank you.
Sincerely,
Someone with known Gadolinium Deposits in the Brain speaking for those who lost their battle. 

5/31/2017 12:52:20 PM
rozakk
I'm not disagreeing with you and clearly this is an area needing more investigation , but have their been any studied indicating a link between gad deposits in brain and morbidity? Also do you know that these problems involve largely a specific set of gad agents (and a set that really should be banned), but not all gad agents?

5/31/2017 2:26:25 PM
Free Bird
Yes. All (GBCA) Linear agents should be banned!!! I would gladly volunteer myself for study to protect others lives.
I also think there should be a dose restriction of macrocyclic agents to 0.1mmol/kg only. If needed only.
As in my case - MD's are not educated and do not even know what the contrast is and will order it because they think the Radiologist will get the best views! There is lack of education in our medical community. These MDs order MRI's with contrast & there is no contrast even needed. Like Mom & apple pie - so to say.  The FDA say they are informing the MD's and the community - NOT. Very sad. I had an awesome wonderful life as a RN until I was injected with Magnevist -  Because A MD thought it would give a better view. That MRI was normal. The story is endless. There are many affected from both agents because of incompetency. So with that being said I feel all Linear Agents Should be Banned and a cure be found to remove gadolinium from the body. 

5/31/2017 2:30:11 PM
hey
*hey grabs the popcorn*

5/31/2017 2:34:58 PM
Jimboboy
haha
wait he's serious.
or is he?
oh wait.
erm...
what the?

(what went through my head as I read freebirds post)