VisEn brings molecular imaging probe to market

AuntMinnie.com staff writers

Jun 6, 2007

Optical imaging developer VisEn Medical of Woburn, MA, has released its MMPSense molecular imaging probe for real-time imaging of matrix metallopreoteinase (MMP) related activities in vivo.

The presence of MMP activity is linked to disease phenomena, including cancer propagation, invasion, and metastsis, as well as cardiovascular disease. Developed from VisEn's proprietary fluorescence imaging probe platforms, MMPSense can image MMP activity in tumors and other sites of inflammation in vivo. The probe emits fluorescence in response to MMP activity.

In May, VisEn and its distribution partner in Asia, Olympus Corporation, launched MMPSense, as well as VisEn's AngioSpark nanoparticle-based and molecular imaging probes, in Japan and other Asian markets.

By AuntMinnie.com staff writers
June 7, 2007

Related Reading

VisEn, Merck to develop molecular imaging agents, March 6, 2007

VisEn, Olympus expand distribution relationship, December 11, 2006

Olympus, VisEn ink Japanese deal, December 11, 2006

VisEn debuts optical imaging probes, March 28, 2006

Analogic to provide FMT systems to VisEn Medical, June 7, 2004

Copyright © 2007 AuntMinnie.com

Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.

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