Germany's rising stars step into limelight at RSNA

By Philip Ward, staff writer

December 4, 2013 -- CHICAGO - More than 30 of Germany's brightest researchers have grabbed the opportunity to display their talents to a global audience at RSNA 2013 in a lavish government-funded initiative.

Quantitative Imaging in Oncology
The Quantitative Imaging in Oncology research network is one of the eight research networks featured in the RSNA exhibition. It has developed a workflow software solution that creates visualizations, schematics, and statistics according to quantitative criteria based on image data. Image courtesy of BMBF.

For the second consecutive year, the German Federal Ministry of Education and Research (BMBF) has laid on an exhibition at RSNA showcasing the work of eight groups. The 90-sq-m booth, located in the South Hall of McCormick Place (No. 2965), is part of the international marketing initiative "Germany -- Partner for Medical Technology" under the umbrella of "Research in Germany -- Land of Ideas." The BMBF aims to promote the merits of Germanby as a hot spot for scientific research and industrial innovation.

Computer scientist Dr. Michael Teistler of the Flensburg University of Applied Sciences is one the exhibitors. He is working on the interface between human and machine by using off-the-shelf 3D game controllers to enable radiologists to navigate through CT, MR, and other images more quickly and easily. The device enables medical students to practice the sometimes difficult navigation through ultrasound images, and Teistler was honored for this work with a magna cum laude award in the Informatics Education Exhibits category at RSNA 2012.

"Our main aim at the congress is to establish contacts to get evaluation and feedback on the project," he said. "It's so far so good. One senior radiologist from Germany has already told me he wants to try it out in his department."

Teistler has collaborated with Dr. James Brunberg and J. Anthony Seibert, PhD, of the University of California, Davis, and Dr. Jeremy Collins and Pattanasak Mongkolwat, PhD, of Northwestern University in Chicago. By twisting and turning the controller, radiologists can see the beating heart or blood vessels in the brain from any angle. This navigation advancement may help doctors plan complicated cardiac procedures more effectively because the technique makes image viewing easier, more precise, and faster.

Dr. Michael Teistler
Teistler meets Teistler: As part of the Flensburg University of Applied Sciences' RSNA exhibit, Dr. Michael Teistler has starred in a video himself -- though he stressed that the distinctive pink shirt and tie are not his own.

Leif Schröder, PhD, of the Leibniz Institute for Molecular Pharmacology (FMP) is another beneficiary of the ministry's investment. His work is designed to provide insights at the cellular level. Using xenon gas biosensors, he combines the advantages of MRI with those of PET. Hyperpolarized xenon emits stronger signals in MRI than hydrogen atoms, and this nontoxic inert gas is simply inhaled and then "trapped" in a cage of biosensors within the body, which attach themselves to certain cells. Thanks to the strong signals of the xenon, the biosensors are clearly recognizable in the MR image, which is color-coded. Therefore, differences in the tissues are visible at the cellular level -- without the requirement of mass quantities, as is required with MRI.

Not only tumors, but in theory all pathological changes in the body with a certain molecular signature can be diagnosed using this technique, such as plaque deposits in atherosclerosis or inflammation in cardiac tissue. This would help doctors diagnose cancer patients earlier.

Leif Schröder, PhD
Molecular man: Leif Schröder, PhD, of the Leibniz Institute for Molecular Pharmacology.

Schröder works closely with researchers at the University of California, Berkeley, who are experts in the chemical synthesis of the biosensors. The team of physicists has developed advancements in the hyperpolarizer, which is important in the magnetization of xenon; they incorporated a more powerful laser and designed a targeted temperature management to counter the overheating of the device that interrupted the hyperpolarization process.

The other six research networks exhibiting at RSNA are 3D Imaging in Medicine, BioNanoMedTech, Quantitative Imaging in Oncology (QUINO), the Solution Center for Image Guided Local Therapies (STIMULATE), the Fraunhofer Institute for Medical Image Computing MEVIS, and MeVis Medical Solutions, which specializes in image-based early detection and diagnostics of breast, lung, liver, prostate, and intestinal cancer, as well as neurological diseases.

3D imaging in medicine
The 3D Imaging in Medicine research network uses a time-of-flight camera mounted on an MRI or CT machine to record movements in 3D. This method of respiratory gating can more accurately target tumors in the lung, for example, sparing surrounding tissues. Image courtesy of BMBF.
Fraunhofer Institute for Medical Image Computing
The Fraunhofer Institute for Medical Image Computing MEVIS helps facilitate the safe use of tablet computers to access data during surgical procedures. Image courtesy of Fraunhofer MEVIS/Fabian Bimmer.

Germany is a leader in the international medical technology community, boasting between 5% and 20% of scientific publications related to medical technology (depending on the topic). According to the BMBF, the German medical technology sector has a world market share of 14.6% and ranks second behind the U.S. No decision has been made yet about whether the BMBF plans to exhibit at RSNA again next year, but it remains a possibility, the organizers said.

Copyright © 2013

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