Voxel-based morphometry is an advanced computer-based method that analyzes an MR brain image and constructs a mathematical model, allowing the researchers to assess the relationship between an active lifestyle and gray-matter volume.
Dr. Cyrus Raji, PhD.
"Gray matter is important because it houses neurons, which shrink or die when you have a neurodegenerative disease such as Alzheimer's," lead study author Dr. Cyrus Raji, PhD, a radiology resident at the University of California, Los Angeles, told AuntMinnie.com. "If we can stop those processes or slow them down, then that can be reflected in preserved [gray-matter] volume."
For this study, Raji and colleagues recruited adults from the Cardiovascular Health Study (CHS), a four-site, population-based study of coronary heart disease and stroke. CHS contains some 20 years of clinical data on this patient population, including body mass index and lifestyle habits.
They selected a total of 876 adults with an average age of 78 years and used a standardized questionnaire on 15 physical activities they participated over the course of two weeks. The activities were swimming, hiking, aerobics, jogging, tennis, racquetball, walking, gardening, mowing, raking, golfing, bicycling, dancing, calisthenics, and riding an exercise cycle.
The researchers reviewed those activities and calculated energy output to determine kilocalories burned per week. In doing so, they found that the more kilocalories burned, the larger the gray-matter volume in the frontal, temporal, and parietal lobes, including the hippocampus, posterior cingulate, and cerebellum, in all 876 individuals.
"The relationship between an active lifestyle as measured by kilocalories and gray-matter volume was a powerful one," Raji said. "Even when accounting for factors such as age, gender, body mass index, study site, and head size, it did not change the results."
The relationship between calories burned and gray-matter volume in both sides of the brain is shown in green, yellow, and red. The colors show areas that are larger in volume with increased calories burned. Video courtesy of Dr. Cyrus Raji, PhD.
Raji and colleagues also conducted a separate analysis of individuals with Alzheimer's and mild cognitive impairment and found that those individuals also benefited from physical activity.
"While physical activity cannot cure Alzheimer's, our study participants with Alzheimer's who were very active had reduced brain atrophy," Raji said. "All of the brain areas in our study positively affected by an active lifestyle are involved with cognition, such as the temporal lobes. That makes sense, because [these brain regions] use the most energy and require the most oxygen and glucose."
Neurons require oxygen and glucose to function and need constant blood flow for a consistent supply because they cannot make or store them. Physical activity can maintain an optimal supply of oxygen and glucose by increasing blood flow to the brain.
One other key aspect of the study was its focus on a variety of physical activities. Raji and colleagues noted that it is not one but a combination of lifestyle choices and activities that benefit the brain.
"What struck me the most about these results is that we have in one of the largest multisite, voxel-based brain imaging studies ever done a finding of how an active lifestyle can benefit the brain in normal aging and Alzheimer's," Raji said. "That's important evidence for using this as a prevention strategy for Alzheimer's because different types of physical activity can benefit the brain -- not just one."
The researchers plan to build upon their findings by studying the underlying genetics of obesity and Alzheimer's disease.
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