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Giant Cell Interstitial Pneumonia:

Clinical:

Giant cell interstitial pneumonia (GIP) is a rare form of pulmonary fibrosis caused by exposure to metal compounds such as cobalt or tungsten carbide [1]. GIP is considered a pneumoconiosis [1]. In the condition, the interstitium and alveolar walls are thickened by mononuclear cells, and the diagnostic feature of GIP is the presence of a large number of giant cells filling the air spaces [1].

X-ray:

Findings on HRCT include ground-glass opacities, reticular/irregular linear densities, and enlarged mediastinal lymph nodes [1]. Honeycombing can also be seen [1].

REFERENCES:

(1) AJR 2005; Choi JW, et al. Giant cell interstitial pneumonia: high-resolution CT and pathologic findings in four adult patients. 184: 268-272

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