RT may not be needed for seniors with breast cancer subtype
Article Thumbnail ImageApril 4, 2012 -- Radiation therapy may not be necessary for women with the luminal A subtype of breast cancer, especially if they are older than 60, according to study results presented at the American Association of Cancer Research (AACR) meeting held this week in Chicago.
Member Sign In:
  MemberID or E-mail Address:

New AuntMinnie.com Members

Becoming a Member is FREE!

  • Real-time radiology-specific news
  • Case of the Day and Teaching Files
  • Focused topics digital communities
  • Lively, discussion groups
  • Medical imaging bookstore
  • SalaryScan
  • Job Boards
  • Online CME
  • Bookstore, market reports, more …
  • Conference Calendar
  • User-controlled eNewsletters
  • … registration is FREE and easy!
  • A Canadian research team performed molecular subtyping on 304 tumor blocks from 769 women with cancer who had been enrolled in a randomized clinical trial in which they received hormone therapy treatment (tamoxifen) and whole-breast radiation therapy treatment or hormone therapy alone. Based on the immunohistochemistry results, the patients were classified into six categories, one of which was luminal A. Luminal A was defined as ER-positive, PR-positive, HER2-negative, and low Ki-67.

    Patients were followed for 10 years, Dr. Fei-Fei Liu, staff radiation oncologist at Princess Margaret Hospital in Toronto, Ontario, and professor of radiation oncology at the University of Toronto, told attendees.

    Women in the luminal A subgroup had the best outcome, with a 10-year risk for local relapse of 8% with hormone therapy alone versus 4.6% for the combined treatment. Women in this subgroup older than 60 had a local relapse rate of 4.3% and 6%, respectively, suggesting that radiotherapy treatments did not influence the long-term recurrence outcomes of this group of patients.

    However, the addition of radiation therapy was beneficial for the other five breast cancer subgroups. In the luminal B subgroup, for example, women who had hormone treatment only had a recurrence rate of 16.1% compared with a rate of 3.9% who had the combined treatment.

    || About || Advertising || AuntMinnieCME.com || Bookstore || Breast MRI || Career Center || Case of the Day || Communities || Conferences || Contact Us || ECR News 2014 || Education || Equipment Classifieds || Europe || Facebook || Forums || Home || Links || Marketplace || Middle East || Mobile || Molecular Breast Imaging || New Installations || News in Brief || People in the News || Privacy Policy || RSNA News 2013 || Reference || Salary Survey Results || Trends in Radiology || Twitter || Vendor Connect || Webinars || XML/RSS ||

    Copyright © 2014 AuntMinnie.com. All Rights Reserved.