Avid launches phase II trial

AuntMinnie.com staff writers
Jun 8, 2008

Avid Radiopharmaceuticals has begun a phase II clinical trial for its F-18-AV-45 molecular imaging compound for Alzheimer's disease.

The large-scale multicenter trial will evaluate Avid's PET molecular imaging agent for visualizing amyloid plaques, according to the Philadelphia-based firm. Approximately 200 patients will be enrolled at more than 30 centers in the U.S.

Related Reading

Avid launches clinical trial, October 3, 2007

Bayer Schering Pharma licenses Avid's imaging agent, June 19, 2007

UPenn study awarded SNM Small Animal Image of the Year, June 15, 2007

Avid nets financing, May 10, 2007

Avid releases results for PET Alzheimer's agent, March 23, 2007

Copyright © 2008 AuntMinnie.com

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Examples in two patients. (Top) Abnormal leukocyte accumulation was observed in the right 1st to 5th toes, with the radioactive lesions extending to the bone, indicating osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). Two spherical VOIs were drawn on diabetic foot infections (DFIs) and the highest SUVmax was 4.2 (higher than the cutoff of 1.1) Despite intensive treatment, the infection progressed, leading to the patient undergoing right below knee amputation 43 days after SPECT/CT. (Bottom) Mild focal abnormal leukocyte accumulation was detected in the right 3rd and 4th toes. The lesions were in contact with the bone, which raised a suspicion of osteomyelitis (left panel, MIP image; right panel, axial SPECT/CT). A circular VOI was drawn on DFIs and the SUVmax was 1.0 (lower than the cutoff of 1.1). After 10 weeks of antibiotic treatment, the infection was successfully resolved, and the foot was preserved. Image and caption courtesy of Scientific Reports.
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